943518-63-6

Usage

Uses

Used in Pharmaceutical Industry:
Itopride Impurity A is used as a quality control parameter for ensuring the safety and efficacy of itopride formulations. Its presence is monitored and controlled to maintain the specified limits, which is crucial for meeting regulatory requirements and upholding the quality standards of itopride pharmaceutical products.
Itopride Impurity A is used as a monitoring agent for the production process of itopride, ensuring that the levels of this impurity are kept within acceptable ranges to prevent any potential adverse effects on patients and to maintain the overall quality of the medication.
Regular testing and monitoring for the presence of Itopride Impurity A are essential in the pharmaceutical industry to ensure the safety and efficacy of itopride formulations for patient use, thereby contributing to the overall well-being and health of individuals relying on this medication for gastrointestinal disorders.

Upstream product

• 696-60-6 4-aminomethylphenol 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 93-07-2 Veratric acid 
• 50-00-0 formaldehyd 
• 1521-41-1 veratramide 
• 108-95-2 phenol 

Downstream Products

• 122898-67-3 itopride 
• 122892-31-3 N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide hydrochloride 

Relevant academic research and scientific papers

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i

Method for preparing amide from carboxylic acid under irradiation of blue light by taking iridium and cobalt complexes as catalysts

The invention relates to a method for preparing amide from carboxylic acid under the irradiation of blue light by taking iridium and cobalt complexes as catalysts, and belongs to the field of chemistry. The method comprises the following step of: by taking R substituted carboxylic acid and R1' and R2' substituted amines as raw materials, triphenylphosphine as a deoxidizing agent, [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as a photocatalyst and Co(dmgH)(dmgH2)Cl2 as a metal complex catalyst, reacting in dichloromethane in an inert atmosphere and under the irradiation of blue light to obtain an amide compound, wherein R is an aryl group, a heteroaryl group, a protected amino group, a substituted alkyl group, a substituted aryl group or a substituted protected amino group, R1' is a hydrogen group, a substituted alkyl group, a phenyl group or a substituted phenyl group, and R2' is a hydrogen group, a substituted alkyl group, a phenyl group or a substituted phenyl group.

Synthesis method of itopride hydrochloride

The invention discloses a synthesis method of itopride hydrochloride, and relates to the technical field of organic synthesis. Hydroxybenzylamine is taken as starting material, in non-polar solvent, in the presence of an acid-binding agent, the Hydroxybenzylamine and 3,4-dimethoxybenzoyl chloride are subjected to amidation to obtain an intermediate N-(4-hydroxyl) benzyl-3,4-dimenthoxybenzamide, and in polar solvent, in the presence of a catalyst, the intermediate N-(4-hydroxyl) benzyl-3,4-dimenthoxybenzamide and 2-chlorine-N,N-dimethylethylamine are subjected to etherification to obtain the itopride hydrochloride. According to the method, the raw materials are easy to obtain, the route is short, only two steps of synthetic reactions are needed, the high yield of 85-97% can be achieved in each step, by means of amidation and etherification with high product purity, a dangerous process of high-pressure hydrogenation is avoided successfully, and meanwhile, the production and raw materialcosts are greatly reduced.

Preparation method of itopride hydrochloride

The invention relates to a preparation method of itopride hydrochloride and belongs to the technical field of raw material preparation. The technical scheme is as follows: the preparation method of itopride hydrochloride comprises the steps as follows: an intermediate I is prepared from initial materials including 3,4-dimethoxybenzamide, formaldehyde and phenol with a one-pot method; the intermediate I and N,N-dimethyl chloroethane hydrochloride are subjected to a substitution reaction to produce an intermediate II; finally, itopride hydrochloride is prepared through salification. The itopridepreparation process comprises a short and convenient route and is economical and environmentally friendly.

NOVEL PROCESS FOR SYNTHESIS OF ITOPRIDE AND ITS NOVEL INTERMEDIATE N-(4-HYDROXYBENZYL)- 3,4-DIMETHOXYBENZAMIDE

The present invention relates to a novel and improved process for the preparation of N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide—known as Itopride, via a novel intermediate N-(4?hydroxybenzyl)-3,4-dimethoxybenzamide.

A NOVEL PROCESS FOR SYNTHESIS OF ITOPRIDE AND IT’S NOVEL INTERMEDIATE-N-(4-HYDROXYBENZYL)-3,4-DIMETHOXYBENZAMIDE

The present invention relates to a novel and improved process for the preparation of N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide-known as Itopride, via a novel intermediate N-(4~hydroxybenzyl)-3,4-dimethoxybenzamide.