152123-58-5

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 98-86-2 acetophenone 
• 100-52-7 benzaldehyde 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 

Downstream Products

• 1372764-88-9 2,2-difluoro-3(R)-hydroxy-3-phenyl-N-((S)-1-phenylethyl)butanamide 
• 1372764-87-8 2,2-difluoro-3(S)-hydroxy-3-phenyl-N-((S)-1-phenylethyl)butanamide 
• 206346-84-1 3,3-Difluoro-4-methyl-4-phenyloxetan-2-one 
• 700-59-4 β,β-difluoro-α-methylstyrene 

Relevant academic research and scientific papers

An effective synthesis of 2,2-difluoro-3-hydroxy esters

Reformatsky reactions of bromodifluoroacetate with carbonyl compounds and its applications to the synthesis of 2,2-difluoro-3-hydroxy esters as a means of two-carbon homologation with a difluoro moiety under mild conditions in good to excellent yields are

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.

Indium-promoted reformatsky reaction: A straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds

A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines,

Indium-promoted reformatsky reaction: A straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds

A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines,

Rhodium-catalyzed Reformatsky-type reaction of ethyl bromodifluoroacetate

Treatment of a variety of carbonyl compounds with ethyl bromodifluoroacetate and Et2Zn in the presence of RhCl(PPh 3)3 in CH3CN afforded Reformatsky-type products in good to excellent yields in a mild reaction c

Synthesis of 1,1-difluoroalkenes via α,α-difluoro-β-lactones

A new method for the general synthesis of 1,1-difluoroalkenes from ketones is presented.The procedure involves initial condensation of a ketone with the difluoro Reformatsky reagent, hydrolysis to form the α,α-difluoro-β-hydroxy acids, followed by cycliza

Nucleophilic introduction of fluorinated alkyl groups into aldehydes and ketones using the corresponding alkyl halide with samarium(II) iodide

Fluorinated alkyl groups such as PhCF2, C6F13, CF3CCl2 and CF2CO2Et are nucleophilically introduced into an aldehyde or ketone using fluorinated alkyl halides with SmI2/sub

Practically useful Reformatsky type reactions of chlorodifluoroacetate and bromodifluoroacetate induced by samarium(II) diiodide

Treatment of XCF2COOEt (X = Cl and Br) with SmI2 in THF gave efficiently β,β-difluorinated enolate equivalent, which was used for Reformatsky type reaction with aldehydes and ketones to give 2,2-difluoro-3-hydroxy ester.

Preparation of α,α-Difluoro-β-hydroxy Esters via a Modified Reformatsky Reaction

A modified Reformatsky reaction has been developed which allows for the reproductible preparation of α,α-difluoro-β-hydroxy- and γ-amino-α,α-difluoro-β-hydroxy esters in good yield from the corresponding aldehyde, ketone, or α-N-carbamoyl aldehyde.