15225-85-1

Usage

InChI:InChI=1/2C6H11NS2.Cu/c2*8-6(9)7-4-2-1-3-5-7;/h2*1-5H2,(H,8,9);/q;;+2/p-2

Upstream product

• 873-57-4 sodium piperidinedithiocarbamate 
• 110-89-4 piperidine 
• 75-15-0 carbon disulfide 
• 12775-96-1 copper 
• 110-86-1 pyridine 
• 136-04-9 potassium 1-piperidinecarbodithioate 
• 49791-55-1 ammonium pentamethylenedithiocarbamidate 
• 7758-99-8 copper(II) sulfate 

Relevant academic research and scientific papers

A reassignment of the EPR spectra previously attributed to Cu@C 60

EPR spectra attributed to the endohedral metallofullerene Cu@C60 are better explained by the previously characterized Cu(ii) dithiocarbamate family of compounds. The Royal Society of Chemistry.

Synthesis, chemical characterization and cancer cell growth-inhibitory activities of Cu(ii) and Ru(iii) aliphatic and aromatic dithiocarbamato complexes

In this paper, we focused on the analysis of the effects mediated by different cyclic dithiocarbamic ligands (DTC) on three classes of antiproliferative coordination compounds, namely, Ru(iii) complexes with the general formulae [Ru(DTC)3] and [Ru2(DTC)5]Cl, and the neutral Cu(ii) derivatives of the type [Cu(DTC)2]. In particular, we present the synthesis and characterization of a library of total 23 coordination compounds containing Ru(iii) or Cu(ii) as the biologically-active metal center and two or more dithiocarbamato (DTC) ligands derived from cyclic amines (aliphatic or aromatic). Several techniques including elemental analysis, X-ray crystallography, ESI-MS, 1H-NMR spectroscopy, FT-IR and UV-Vis spectrophotometry were used to characterize the compounds, which highlighted the different electronic behaviors generated by the substituents within the DTC moiety. Moreover, the synthesized compounds were tested for their stability in order to investigate their antiproliferative activity against 3 human cancer cell lines, namely, HeLa, HepG2 and HepG2/SB3. In particular, HepG2/SB3 was chosen for its aggressiveness due to upregulation of the anti-apoptotic protein SerpinB3. Finally, the most promising compounds are studied in terms of log?P. Overall, the results reveal the drug-likeness of some of the derivatives of copper(ii) and ruthenium(iii).

Composition and Structure of Complexes in Magnetically Diluted Systems of Copper(II) Dithiocarbamates Cu/M(Dtc)2 (M = Zn, Cd, Hg)

The magnetically diluted complexes Cu/M(Dtc)2 (where M = Zn, Cd, or Hg, and Dtc is the dibutyl-, pentamethylene-, hexamethylene-, or morpholinedithiocarbamate ligand) were studied by EPR. In these systems, copper(II) forms four types of complexes: the mononuclear Cu(Dtc)2 complexes, the CuM(Dtc)4 dimers, and some heteronuclear species resulting from the substitution of one copper atom for a metal atom in the binuclear or mononuclear parts of the adduct-like polynuclear complexes M2(Dtc)4 · nM(Dtc)2 (n = 1-4). The geometry of the copper(II) coordination polyhedra is discussed for all the complexes identified. Structural instability of some of these magnetically diluted systems is attributed to lability of the polynuclear species.

Adduct Formation in Solid Phase: EPR and Stoichiometric Studies of the Adducts of Heterometallic Binuclear Copper Zinc Dithiocarbamates CuZn(Dtc)44 (Dtc = Cyclic Dithiocarbamato Ligands) with Pyridine

The adducts of magnetically diluted binuclear copper zinc dithiocarbamates, based on piperidine-, hexamethylene-, and morpholinedithiocarbamato ligands with pyridine are studied by EPR spectroscopy. The stoichiometric composition of the adducts formed upon pyridine absorption corresponds to the 1: 1 metal-to-pyridine ratio. Two types of adducts are identified: dimers CuZn(Dtc)4 · 2Py and monomers M(Dtc)2 · Py. The geometry of the coordination polyhedra in both dimers and monomers is close to trigonal-bipyramidal.

THE DIRECT ELECTROCHEMICAL SYNTHESIS OF DIALKYLDITHIOCARBAMATE AND DIETHYLDITHIOPHOSPHATE COMPLEXES OF MAIN GROUP AND TRANSITION METALS

Dialkyldithiocarbamate derivatives (R2NCS2)nM of a number of metals (M=Fe, Co, Ni, Cu, Ag, Zn, Cd, In, Tl) have been synthesised in good yield by electrochemical oxidation of appropriate sacrificial anodes in non-aqueous solutions of either the corresponding tetraalkylthiuran disulphide (R2NCS2)2 (R=Me, Et) or a mixture of carbon disulphide plus the secondary amine R2NH (R=Et, i-Pr; R2NH=piperidine).Similar experiments with solutions of (EtO)2P(S)SH (=HL) gave MLn* derivatives (M=Fe, Co, Ni, Cu, Ag, Au, Zn, Cd, Hg, Ga, In, Tl) while in the presence of HL+1,10-phenanthroline, MLn.phen derivatives were obtained for M=V, Mn, Fe, Co, Zn, and Ga.