1523-20-2

Upstream product

• 99-34-3 3,5-dinitrobenzoic acid 
• 108-95-2 phenol 
• 99-33-2 3,5-dinitrobenoyl chloride 
• 139-02-6 sodium phenoxide 
• 1523-21-3 4-nitrophenyl 3,5-dinitrobenzoate 
• 3229-70-7 phenolate 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 610-30-0 2,4-dinitrobenzoic acid 
• 102-09-0 bis(phenyl) carbonate 

Downstream Products

• 99-34-3 3,5-dinitrobenzoic acid 
• 3229-70-7 phenolate 

Relevant academic research and scientific papers

Preparation and use of lithium tritide and lithium trimethoxyborotritide

Two new tritide reducing agents, Li3H and Li(CH3O)3B3H, have been prepared at the carrier-free level and used to reduce 2-naphthaldehyde to tritiated β-naphthalene methanol, to produce C3H3OR, and to synthesize a methyl-tritiated secondary amine.

Palladium Catalyzed Regioselective Cyclization of Arylcarboxylic Acids via Radical Intermediates with Diaryliodonium Salts

Palladium-catalyzed C2-arylation/intramolecular acylation with arylcarboxylic acids was developed by using diaryliodonium salts. The protocol has the advantage of good step-economy by two chemical bonds formation in one pot.

Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors

Human 5-lipoxygenase (5-LOX) is a well-validated target for anti-inflammatory therapy. Development of novel 5-LOX inhibitors with higher activities is highly demanded. In previous study, we have built a model for the active conformation of human 5-LOX, and identified naphthalen-1-yl 3,5-dinitrobenzoate (JMC-4) as a 5-LOX inhibitor by virtual screening. In the present work, 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors were developed. Twenty aryl 3,5-dinitrobenzoates, N-aryl 3,5-dinitrobenzamides and analogues were designed and synthesized. Several of them were found with significantly increased activities according to cell-free assay and human whole blood assay. The structure-activity relationship study may provide useful insights for designing effective 5-LOX inhibitors.

Kinetics and mechanism of phosphate-catalyzed hydrolysis of benzoate esters: Comparison with nucleophilic catalysis by imidazole and o-iodosobenzoate

Phosphate-catalyzed hydrolysis of 2,4-dinitrophenyl 4-X-benzoate, and 3- or 4-Y-phenyl 3,5-dinitrobenzoates, where X and Y are substituents, has been studied spectrophotometrically. The following conclusions are based on catalytic rate constants, solvent

Nucleophilic displacement at the benzoyl centre: A study of the change in geometry at the carbonyl carbon atom

The second-order rate constants for the reaction between hydroxide ion and phenoxide ion with 4-nitrophenyl esters of substituted benzoic acids in 10% acetonitrile-water (v/v) solution obey Hammett σ correlations. The values of the Hammett ρ of 1.67 (κArO) and 2.14 (κOH) are consistent with a large change in hybridization at the central carbon by comparison with the ρ value for a standard reaction where a full sp2 to sp3 change occurs. The transition state for the concerted reaction thus has a substantially tetrahedral geometry. The observation of the anti-Hammond effect whereby the ρ value for the hydroxide ion exceeds that of the less reactive phenoxide ion is consistent with a concerted, ANDN, mechanism for these reactions. A stepwise mechanism, AN + DN, is unlikely to yield a measurable break in the Hammett correlation for a change in the benzoyl substituent if the partitioning of the putative tetrahedral intermediate involves forward and reverse reactions with Hammett correlations possessing similar ρ values.