152302-86-8

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 696-62-8 para-iodoanisole 
• 77629-83-5 ethyl 2-bromo-2-(4-methoxyphenyl) acetate 
• 122-52-1 triethyl phosphite 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 100-66-3 methoxybenzene 
• 36141-66-9 ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 40140-16-7 ethyl (p-methoxyphenyl)oxoacetate 

Relevant academic research and scientific papers

Route to α-Aryl Phosphonoacetates: Useful Synthetic Precursors in the Horner-Wadsworth-Emmons Olefination

A versatile and general catalytic strategy has been developed for the α-arylation of phosphonoacetates utilizing parallel microscale experimentation. These α-substituted phosphonoacetates are widely useful, notably as substrates in the Horner-Wadsworth-Emmons-type olefinations. However, the current routes to these products involve harsh conditions, limiting the variety of functionality. The reported method can be used with a variety of aryl chlorides and aryl bromides, including several heterocyclic examples.

Reliable and versatile synthesis of 2-aryl-substituted cinnamic acid esters

2-Aryl-substituted phosphono acetates can be readily synthesized by a four-step sequence from the respective arenes. Succeeding Horner-Wadsworth- Emmons olefinations provide stereoselectively the 2-aryl cinnamic acid esters even when sensitive moieties are involved. Georg Thieme Verlag Stuttgart.

Copper(I) Salt-Mediated Arylation of Phosphinyl-Stabilized Carbanions and Synthetic Application to Heterocyclic Compounds

The copper-mediated reaction of phosphinyl-stabilized carbanions 2a-c with aryl halides 1a-i in DMF or HMPA produced (arylmethyl)phosphonates 3-11 in good yields.Similar treatment of N-(2-iodophenyl)- and N-(2-iodophenyl)-N-methyl-α-(diethoxyphosphinyl)ac