A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'- phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

DOI: 10.1016/S0040-4039(97)00662-X

Source and publish data:

Tetrahedron Letters p. 3483 - 3486 (1997)

Update date:2022-08-04

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Authors:

Branalt, Jonas

Kvarnstroem, Ingemar

Classon, Bjoern

Samuelsson, Bertil

Nillroth, Ulrika

Danielson, U. Helena

Karlen, Anders

Hallberg, Anders

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Article abstract of DOI:10.1016/S0040-4039(97)00662-X

A new short route to epoxide 6b, a pivotal intermediate for the preparation of hydroxyethylamine dipeptide isosteres has been developed. Opening of the epoxide by anthranilic acid, followed by extensions in the P2/P3-region gave the target compounds which were evaluated as HIV-1 protease inhibitors.

Full text of DOI:10.1016/S0040-4039(97)00662-X

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Product name:[(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

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