15231-17-1

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 1575-95-7 N-acetylbenzamide 
• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 77092-12-7 6-phenyl-2,2-dimethyl-1,3-dioxin-4-one 
• 55-21-0 benzamide 
• 82961-73-7 5-((hydroxy)(phenyl)methylene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 4937-87-5 N-hydroxy-2-oxo-2-phenylethanimidoyl chloride 
• 7064-02-0 phenyl (5-phenyl-4,5-dihydroisoxazol-3-yl)methanone 
• 536-74-3 phenylacetylene 

Downstream Products

• 126081-40-1 N-{1-[2-(1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-5-phenyl-1H-pyrazol-3-yl}-benzamide 
• 15969-46-7 2,6-Diphenyl-1H-pyrimidin-4-one 

Relevant academic research and scientific papers

A facile synthesis of pyrimidin-4-ones

A facile synthesis of 2,6-disubstituted pyrimidin-4-ones and 2,5,6-trisubstituted pyrimidin-4-ones from commercially available materials with application of microwave technology in key steps is described.

Synthesis of β-Ketocarboxamide Derivatives Using 2,2-Dimethyl-2H,4H-1,3-dioxin-4-ones

Thermal reaction of 2,2-dimethyl-2H,4H-1,3-dioxin-4-ones (1) with amines was studied.Acylketenes 2, generated by heating of 1, reacted with anilines and benzylamine to give the corresponding β-ketocarboxamides (3,4, and 5) in good yields.The reaction of 1 with ammonia gave 3-amino-2-alkenamides (7), which were hydrolyzed to β-ketocarboxamides (6).The former products 7 were readily transformed to the 6-substituted 2-methyl-3H-pyrimidin-4-ones (9) via the 3-acetamido-2-alkenamides (8).Acylation of O-benzylhydroxylamine with 1 gave the β-ketohydroxamic acids 10.Debenzylation of 10 followed by cyclization gave rise to 5-alkyl-3-hydroxyisoxazoles (12).The reaction of 1 with amides gave the corresponding N-acetylated amides (13). Keywords --- 2H,4H-1,3-dioxin-4-one; thermal fragmentation; acylketene; acylation; carboxamide; hydroxamic acid; 3-hydroxyisoxazole; 3H-pyrimidin-4-one

1,3-Oxazines and Related Compounds. V. N-Acylacetylation of Carboxamides with the Diketene-Halotrimethylsilane System or Acyl Meldrum's Acids

Various aliphatic and aromatic carboxamides smoothly underwent N-acetoacetylation by means of the diketene-iodotrimethylsilane system to give the corresponding N-acetoacetyl derivatives.The diketene-bromotrimethylsilane system was found to be very efficient for N-acetoacetylation of unsaturated carboxamides such as acrylamide and methacrylamide.In addition, acyl Meldrum's acids proved effective for N-acylacetylation of carboxamides, especially heterocyclic carboxamides such as picolinamides.Keywords: carboxamide; acylacetylation; diketene; iodotrimethylsilane; bromotrimethylsilane; acyl Meldrum's acid