19777-66-3

Basic information

• Product Name: (S)-(-)-1,2-Diaminopropane dihydrochloride
• Synonyms: L-1,2-PROPANEDIAMINE DIHYDROCHLORIDE;PROPYLENEDIAMINE DIHYDROCHLORIDE;(S)-(-)-1,2-DIAMINOPROPANE DIHYDROCHLORIDE;(S)-1,2-DIAMINOPROPANE DIHYDROCHLORIDE;(S)-1,2-PROPANEDIAMINE DIHYDROCHLORIDE;(S)-PROPYLENEDIAMINE DIHYDROCHLORIDE;S(-)-PROPYLENEDIAMINE DIHYDROCHLORIDE;(S)-(-)-DIAMINOPROPANE DIHYDROCHLORIDE
• CAS NO: 19777-66-3
• Molecular Formula: C₃H₁₂N₂*2Cl
• Molecular Weight: 147.05
• Product Categories: Amines (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry
• Mol File: 19777-66-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 238-243 °C
• Boiling Point: 215.8 °C at 760 mmHg
• Flash Point: 84.3 °C
• Appearance: /
• Vapor Pressure: 0.12mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Soluble in water
• BRN: 5740936
• CAS DataBase Reference: (S)-(-)-1,2-Diaminopropane dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1,2-Diaminopropane dihydrochloride(19777-66-3)
• EPA Substance Registry System: (S)-(-)-1,2-Diaminopropane dihydrochloride(19777-66-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-23/24/25
• Safety Statements: 26-36-45-36/37/39
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 19777-66-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

Different sources of media describe the Uses of 19777-66-3 differently. You can refer to the following data:
1. (S)-(-)-1,2-Diaminopropane Dihydrochloride is used in the synthesis of Dexrazoxane, a cardiac medicine.
2. (S)-(-)-1,2-Diaminopropane dihydrochloride may be used in the preparation of following chiral imidazoline derivatives, which show moderate α-adrenergic blocking activity:(S)-(-)-4-methyl-2-(1-naphthylmethyl)imidazoline hydrochloride(S)-(-)-2-benzyl-4-methylimidazoline picrate(S )-(-)-2-[(2,6-dichlorophenyl)imino]-4-methylimidazolidine hydrochloride

InChI:InChI=1/C3H10N2.2ClH/c1-3(5)2-4;;/h3H,2,4-5H2,1H3;2*1H/t3-;;/m0../s1

Upstream product

• 7324-05-2 L-alanine amide 
• 146552-71-8 (S)-tert-butyl 1-aminopropan-2-ylcarbamate 
• 78-90-0 1,2-diaminopropan 
• 90-02-8 salicylaldehyde 
• 6531-31-3 4-methyl-imidazolidin-2-one 
• 71810-97-4 D-alaninamide hydrochloride 

Downstream Products

• 112816-32-7 (R)-N-(2-toluenosulfonylamino-1-methyl-ethyl)-toluenesulfonamide 
• 1083366-50-0 (2S)-[N,N'-bis(2'-hydroxy-3',5'-di-tert-butylbenzylidene)]-1,2-diaminopropane 
• 41013-25-6 (2S)-[N,N'-bis(2'-hydroxybenzylidene)]-1,2-diaminopropane 
• 956122-24-0 Acetic acid 3-[4-((R)-2-amino-propylamino)-quinazolin-2-yl]-4-hydroxy-phenyl ester 
• 1613696-59-5 (2R)-N¹-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-nitrophenyl]propane-1,2-diamine 
• 1613696-60-8 (2S)-N¹-[4-(3,5-Dimethyl-1,2-oxazol-4-yl)-2-nitrophenyl]propane-1,2-diamine 
• 121103-15-9 ((S)-2-aminopropyl)carbamic acid tert-butyl ester 
• 78-90-0 (R)-1,2-diaminopropane 
• 1229025-68-6 (S)-benzyl 2-(methoxycarbonylamino)propylcarbamate 
• 15250-41-6 (S)-N,N,N',N'-tetrakis[(hydroxycarbonyl)methyl]-1,2-diaminopropane 
• 333743-54-7 tert-butyl (R)-(2-aminopropyl)carbamate 
• 956124-84-8 2-[4-((R)-2-aminopropylamino)quinolin-2-yl]-4-chlorophenol 

Relevant articles and documents

Schiff base complexes derived from salicylaldehyde with amine, [Ni(1,2-pn)2Cl2]·3H2O and [Cu(1,2-pn)2]SO4·2H2O, as complex ligands

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Synthesis of a water-soluble chiral NMR shift reagent: (S)-PDTA

A five-step synthesis of the water-soluble chiral polydentate ligand, (S)-PDTA [(S)-PDTA = N,N,N′,N′-tetrakis[(hydroxycarbonyl)methyl]-(S)-1,2-diaminopropane] starting from l-alanine has been worked out, via steps with retention of chirality. Total yield is 50.7% (average of ～88% for each step), while published methods report 33.4% total yield over four steps.

Synthesis, Characterization, and Optical Properties of New Organic–Inorganic Hybrid Perovskites [(NH3)2(CH2)3]CuCl4 and [(NH3)2(CH2)4]CuCl2Br

Organic–inorganic hybrid perovskites (OIHs) are exceptionally promising sector of novel materials for optoelectronic applications. Herein, the OIHs of the formula [(NH3)2(CH2)3]CuCl4 labeled by C

Simplified syntheses of the water-soluble chiral shift reagents Sm-(R)-pdta and Sm-(S)-pdta

The chiral shift reagents Sm-(R)-pdta and Sm-(S)-pdta, which are based on (R)- or (S)-1,2-diaminopropane-N,N,N′,N′-tetraacetic acid were synthesized from easily accessible compounds in three simple steps, which makes the method suitable for laboratory-scale production. In addition, a new and efficient method for the preparation of pure anhydrous (R)- or (S)-1,2-diaminopropane-N,N,N′,N′-tetraacetic acid was developed.