15284-33-0

Usage

Uses

Used in Pharmaceutical Industry:
1-ethenyl-1H-tetrazol-5-amine is used as a neuroprotective and antioxidant agent for its ability to scavenge free radicals and inhibit lipid peroxidation, thereby protecting brain cells from damage.
Used in Stroke Treatment:
Edaravone is used as a therapeutic agent for the treatment of acute ischemic stroke, where it helps in reducing the damage caused by the lack of blood flow to the brain.
Used in Amyotrophic Lateral Sclerosis (ALS) Treatment:
Edaravone is used as a treatment for amyotrophic lateral sclerosis, where it may slow the progression of the disease by protecting motor neurons from oxidative stress.
Used in Alzheimer's and Parkinson's Disease Research:
Edaravone is used in research for its potential to treat Alzheimer's disease and Parkinson's disease, as it may help in reducing oxidative stress and inflammation associated with these conditions.
Overall, 1-ethenyl-1H-tetrazol-5-amine, or Edaravone, demonstrates a wide range of applications in the medical field, particularly in the treatment and research of neurological disorders, due to its neuroprotective and antioxidant properties.

Upstream product

• 15284-31-8 1-(2-chloroethyl)-5-aminotetrazole 
• 4418-61-5 5-aminotetrazole 
• 108-05-4 vinyl acetate 
• 106-93-4 ethylene dibromide 

Downstream Products

• 150996-53-5 Pd(1-vinyl-5-aminotetrazole)2Cl₂ 
• 150996-52-4 Ni(1-vinyl-5-aminotetrazole)2Cl₂ 
• 150996-51-3 Cu(1-vinyl-5-aminotetrazole)2Cl₂ 

Relevant academic research and scientific papers

Vinyltetrazoles: II. Synthesis of 5-substituted 1(2)-vinyltetrazoles

5-R-Substituted 1(2)-vinyltetrazoles (R = Ar, Alk, CH2=CH, NH2, H) were synthesized by alkylation of 5-R-tetrazoles with 1,2-dibromoethane in the presence of triethylamine in acetonitrile, followed by elimination of triethylamine hydrobromide. Vinylation of dinuclear substrates, such as bis(1H-tetrazol-5-yl)-methane and 1,3-bis(1H-tetrazol-5-yl)benzene, under analogous conditions gave the corresponding N1,N 2′- and N2,N2′-divinyl derivatives.

Preparation of remarkably tough polyHIPE materials via polymerization of oil-in-water HIPEs involving 1-vinyl-5-aminotetrazole

Interconnected microcellular polymeric monoliths having unexpected high mechanical strength have been prepared using the high internal phase emulsion (HIPE) methodology. Oil-in water concentrated emulsions of aqueous 1-vinyl-5amino [1,2,3,4]tetrazole (1-VAT) mixed with a low molar ratio (7%) of N,N′-methylenebisacrylamide as crosslinking agent were prepared using dodecane as dispersed phase and a mixture of hydrophilic surfactants. "Reverse" polyHIPE materials were obtained after radical copolymerization, solvent extraction, and drying. Their morphology, chemical composition, and physicochemical behavior are discussed.

SYNTHESIS OF FUNCTIONALLY SUBSTITUTED N-VINYLTETRAZOLES

5-Alkyl- and 5-aryl-N-vinyltetrazoles (II) are formed during vinyl exchange between 5-substituted tetrazoles (I) and vinyl acetate in the presence of the copper acetate-boron trifluoride etherate catalytic system.The direction of vinylation depends on steric effects and on the electronic nature of the substituents at position 5 of the tetrazole ring.A series of functionally substituted 2-vinyltetrazoles were obtained by nucleophilic substitution of the chlorine in 2-vinyl-5-chloromethyltetrazole.