15288-02-5Relevant academic research and scientific papers
Formation and composition of new optically active compounds
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, (2008/06/13)
The present invention is directed to tetrahydronaphthalene derivatives of α-conindendrin, β-conindendrin, sikkimotoxin, and podophyllotoxin having at least one methyleneoxy bridge wherein the oxygen atom extends to the benzhydrylic carbon atom.
Directed, DDQ-Promoted Benzylic Oxygenations of Tetrahydronaphthalenes
Ramdayal, Frank D.,Kiemle, David J.,LaLonde, Robert T.
, p. 4607 - 4609 (2007/10/03)
Positional preferences for para benzylic oxygenation of tetrahydronaphthalenes by 2,3-dichloro5,6-dicyano-1,4-benzoquinone (DDQ)-aqueous dioxane were investigated by comparing the tetralone products from 6-hydroxy-7-methoxy- and 6-acetoxy-7-methoxy-1,2,3,
Direct Synthesis of Benzophenanthridines and Benzophenanthridones via SRN1 Reactions
Beugelmans, Rene,Chastanet, Jacqueline,Ginsburg, Helene,Quintero-Cortes, Leticia,Roussi, Georges
, p. 4933 - 4938 (2007/10/02)
A straightforward and high-yield route to the 11,12-dihydrobenzophenanthridine (3) and 11,12-dihydrobenzophenanthridone (14) ring systems is based upon an SRN1 reaction between 2-halobenzylamines 1 or 2-halobenzoic acids 11 and enolates derived from tetralones 2.The efficient dehydrogenation of 3 or 14 gives the benzophenthridines 4 or benzophenanthridones 15.Use of properly substituted reactants leads to nitidine, avicine, and fagaronine and to analogues of those natural products.
