57596-01-7Relevant articles and documents
Synthesis of benzo[c]phenanthridine alkaloids by Pd(OAc) 2-induced direct aromatic carbonylation
Kumazawa, Eri,Tokuhashi, Takashi,Horibata, Akiyoshi,Tokuda, Masao,Orito, Kazuhiko,Kurono, Nobuhito,Senboku, Hisanori,Ohkuma, Takashi
, p. 4622 - 4633,12 (2020/08/31)
The Pd(OAc)2-induced carbonylation of alkoxy-substituted 1-amino-2-phenyltetralins and 1-amino-2-phenylnaphthalenes was examined to provide the benzo[c]phenanthridine ring system. The carbonylation of substrates containing methylenedioxy groups
Direct Synthesis of Benzophenanthridines and Benzophenanthridones via SRN1 Reactions
Beugelmans, Rene,Chastanet, Jacqueline,Ginsburg, Helene,Quintero-Cortes, Leticia,Roussi, Georges
, p. 4933 - 4938 (2007/10/02)
A straightforward and high-yield route to the 11,12-dihydrobenzophenanthridine (3) and 11,12-dihydrobenzophenanthridone (14) ring systems is based upon an SRN1 reaction between 2-halobenzylamines 1 or 2-halobenzoic acids 11 and enolates derived from tetralones 2.The efficient dehydrogenation of 3 or 14 gives the benzophenthridines 4 or benzophenanthridones 15.Use of properly substituted reactants leads to nitidine, avicine, and fagaronine and to analogues of those natural products.