15288-81-0Relevant academic research and scientific papers
Synthesis of pyridines and pyrazines using an intramolecular hydroamination-based reaction sequence
Rizk, Toni,Bilodeau, Eric J.-F.,Beauchemin, Andre M.
supporting information; experimental part, p. 8325 - 8327 (2010/01/16)
A management issue! Various pyridines and pyrazines can be efficiently accessed from simple acyclic precursors using an intramolecular hydroamination/isomerization/aromatization sequence (see scheme). ρ-Toluenesulfonic acid (2 mol%) is used to catalyze this novel alkyne annulation, in which the oxime group allows for a subsequent redoxneutral aromatization step to occur.
Stereoselective synthesis of medium-sized cyclic compounds through the intramolecular michael-type reaction utilizing alkyne-hexacarbonyldicobalt complex formation
Inaba, Kennichi,Takaya, Jun,Iwasawa, Nobuharu
, p. 474 - 475 (2008/02/02)
Alkyne-hexacarbonyldicobalt complexes having silyl enol ether and electron-deficient alkene moieties on opposite ends were treated with MeAlCl2 in the presence of 2,6-di-t-butylpyridine in CH 2Cl2 to give synthetically use
Cyclic vinylogous triflate hemiacetals as new surrogates for alkynyl aldehydes
Kamijo, Shin,Dudley, Gregory B.
, p. 5629 - 5632 (2007/10/03)
Cyclic vinylogous triflate hemiacetals can serve as 'synthetic equivalents' for alkynyl aldehydes: treatment of a vinylogous triflate hemiacetal with excess amounts of Grignard reagents produces acyclic alkynyl alcohols in good to high yields. This transf
Preparation and Reaction of Zinc and Copper Organometallics Bearing Acidic Hydrogens
Knoess, H. Peter,Furlong, Michael T.,Rozema, Michael J.,Knochel, Paul
, p. 5974 - 5978 (2007/10/02)
Organozinc and copper ragents bearing unprotected primary or secondary amines or amides or a terminal acetylenic proton were prepared and reacted with various electrophiles in good yields.
