16108-51-3

Basic information

• Product Name: 2 6-DIMETHYLCHROMONE
• Synonyms: 2,6-DIMETHYL-4H-CHROMEN-4-ONE;2 6-DIMETHYLCHROMONE
• CAS NO: 16108-51-3
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.2
• Mol File: 16108-51-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 103-104 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 284.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.150±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2 6-DIMETHYLCHROMONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2 6-DIMETHYLCHROMONE(16108-51-3)
• EPA Substance Registry System: 2 6-DIMETHYLCHROMONE(16108-51-3)

Safety Data

• Hazardous Substances Data: 16108-51-3(Hazardous Substances Data)

Usage

Chromone derivative

It is a derivative of chromone, which is a class of organic compounds that consist of a benzene ring fused to a pyran ring.

Natural occurrence

2,6-Dimethylchromone is commonly found in natural products such as Aglaia and Mesua plants.

Anti-inflammatory

It helps in reducing inflammation in the body.

Anticancer

It exhibits properties that can help in the prevention and treatment of cancer.

Antioxidant

It has the ability to neutralize free radicals, thus protecting cells from oxidative damage.

Treatment of neurological disorders

2,6-Dimethylchromone has been studied for its potential use as a drug in treating various neurological disorders.

Neuroprotective agent

It may help in protecting nerve cells from damage and degeneration.

Natural flavoring agent

2,6-Dimethylchromone has shown promise as a natural flavoring agent in the food and beverage industry.

Unique chemical structure

Its chemical structure is unique, which contributes to its diverse biological activities.

Research and potential applications

The diverse biological activities and unique chemical structure of 2,6-Dimethylchromone make it an interesting target for further research and potential applications in medicine and industry.

Upstream product

• 16636-64-9 1-(2-hydroxy-5-methylphenyl)butane-1,3-dione 
• 121-69-7 N,N-dimethyl-aniline 
• 51423-95-1 2,3-dihydro-2,6-dimethylchromen-4-one 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 1262961-96-5 2-(1-hydroxybut-3-yn-1-yl)-4-methylphenol 
• 106-44-5 p-cresol 
• 7664-93-9 sulfuric acid 
• 56290-52-9 1-(2-methoxy-5-methyl-phenyl)-butane-1,3-dione 
• 10034-85-2 hydrogen iodide 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 137-40-6 sodium proprionate 
• 123-62-6 propionic acid anhydride 
• 127-09-3 sodium acetate 

Downstream Products

• 115918-34-8 4-(2-ethoxy-phenyl)-9-methyl-2-phenyl-3a,4,11a,11b-tetrahydro-chromeno[3,2-e]isoindole-1,3,11-trione 
• 89-56-5 5-Methylsalicylic acid 
• 204914-55-6 [4-(2-Hydroxy-5-methyl-phenyl)-6-methyl-pyrimidin-2-ylsulfanyl]-acetic acid hydrazide 
• 204914-53-4 [4-(2-Hydroxy-5-methyl-phenyl)-6-methyl-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester 
• 672327-67-2 4-Nitro-benzoic acid [1-(6-methyl-4-oxo-4H-chromen-2-yl)-meth-(Z)-ylidene]-hydrazide 
• 672327-65-0 2-Chloro-benzoic acid [1-(6-methyl-4-oxo-4H-chromen-2-yl)-meth-(Z)-ylidene]-hydrazide 
• 672327-64-9 4-Chloro-benzoic acid [1-(6-methyl-4-oxo-4H-chromen-2-yl)-meth-(Z)-ylidene]-hydrazide 
• 672327-66-1 4-Methoxy-benzoic acid [1-(6-methyl-4-oxo-4H-chromen-2-yl)-meth-(Z)-ylidene]-hydrazide 

Relevant articles and documents

An efficient TBHP/TBAI-mediated protocol for the synthesis of 4H-chromen-4-ones from chroman-4-ones via oxidative C–C bond formation

Abstract: A transition metal-free and efficient TBHP/TBAI-mediated protocol has been developed for the synthesis of 4H-chromen-4-ones from chroman-4-ones via oxidative C–C bond formation. It proceeds in the presence of a catalytic amount of tetrabutylammonium iodide and oxidant tert-butyl hydroperoxide (TBHP, 5–6 M in decane) to afford the corresponding products in good to excellent yields. Furthermore, it has been observed that an increase in the concentration of TBHP to 30 mol % drastically increases the yield of 4H-chromen-4-ones, any further increase will lead to a decrease in percent yield. The mechanism of this reaction involves the generation of tertiary butoxide radical initially which by oxidative single-electron transformation is converted to iodochroman-4-one. Later the hydrogen iodide is removed from iodochroman-4-one to give the desired product, i.e. 4H-chromen-4-ones. Moreover, this is a rare example of the n-Bu4NI/TBHP-mediated C–C bond through dehydrogenative reaction. Graphic abstract: [Figure not available: see fulltext.]

Ruthenium-NHC-catalyzed asymmetric hydrogenation of flavones and chromones: General access to enantiomerically enriched flavanones, flavanols, chromanones, and chromanols

Two to four! Readily available flavones and chromones were efficiently converted into four valuable chiral classes of O-heterocycles - flavanones, chromanones, flavanols, and chromanols - by means of an enantioselective Ru/NHC-catalyzed hydrogenation process (see scheme; NHC=N-heterocyclic carbene, PCC=pyridinium chlorochromate). Copyright

Benzopyrans : Part 40 - Alumina mediated transformations of 4-oxo-4H-1- benzopyran-3-carbaldehyde, -3-carboxylic acid and their 2-methylhomologues

In contact with alumina, the title aldehyde 1 (R = H, Me, Cl) gives the chromones 5 and 9,12 whereas the acid 2 affords the chromones 7, 10 and acetophenone 23. Alumina converts the aldehyde 3 to the xanthone 14, and the corresponding acid 4 to the chromone 8 and diketone 24.