152907-85-2Relevant academic research and scientific papers
Thermal decomposition of N-alkylated-2-amino-benzophenones
Creencia, Evelyn Cuevas,Takashashi, Atsushi,Horaguchi, Takaaki
, p. 1549 - 1556 (2009)
Thermal decomposition of N-alkylated 2-aminobenzophenones 1a-d was studied at 400-560 °C, using calcium oxide as catalyst. The reactions yielded both 5- and 6-membered heterocyclic compounds. The N-methylated-2-aminobenzophenones 1a-b decomposed at 400-56
NOVEL PROBE COMPOUNDS FOR FLUORESCENCE AND/OR CIRCULAR DICHROISM SENSOR FOR AMINE COMPOUNDS INCLUDING AMINO ALCOHOLS, AND SIMULTANEOUS ANALYSIS METHOD OF FLUORESCENCE AND CIRCULAR DICHROISM
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Paragraph 0115-0117, (2020/12/01)
The present disclosure relates to a novel probe compound, i.e., 1-(ortho-benzophenylaminoalkyl)-phenylboric acid, or its derivative for a fluorescence and/or circular dichroism (CD) sensor for amine compounds containing aminoalcohols. Also, the present disclosure relates to a simultaneous analysis method of fluorescence and CD of amine compounds containing aminoalcohols using the novel probe compound.
NOVEL PROBE COMPOUNDS FOR FLUORESCENCE AND/OR CIRCULAR DICHROISM SENSOR FOR AMINE COMPOUNDS INCLUDING AMINO ALCOHOLS, AND SIMULTANEOUS ANALYSIS METHOD OF FLUORESCENCE AND CIRCULAR DICHROISM
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Paragraph 0152-0155, (2020/12/19)
The present disclosure relates to a novel probe compound, i.e., 1-(ortho-benzophenylaminoalkyl)-phenylboric acid, or its derivative for a fluorescence and/or circular dichroism (CD) sensor for amine compounds containing aminoalcohols. Also, the present disclosure relates to a simultaneous analysis method of fluorescence and CD of amine compounds containing aminoalcohols using the novel probe compound.
Enantioselective Synthesis of Indolines, Benzodihydrothiophenes, and Indanes by C?H Insertion of Donor/Donor Carbenes
Souza, Lucas W.,Squitieri, Richard A.,Dimirjian, Christine A.,Hodur, Blanka M.,Nickerson, Leslie A.,Penrod, Corinne N.,Cordova, Jesus,Fettinger, James C.,Shaw, Jared T.
supporting information, p. 15213 - 15216 (2018/10/31)
We employ a single catalyst/oxidant system to enable the asymmetric syntheses of indolines, benzodihydrothiophenes, and indanes by C?H insertion of donor/donor carbenes. This methodology enables the rapid construction of densely substituted five-membered rings that form the core of many drug targets and natural products. Furthermore, oxidation of hydrazones to the corresponding diazo compounds proceeds in situ, enabling a relatively facile one- or two-pot protocol in which isolation of potentially explosive diazo alkanes is avoided. Regioselectivity studies were performed to determine the impact of sterics and electronics in donor/donor metal carbene C?H insertions to form indolines. This methodology was applied to a variety of substrates in high yield, diastereomeric, and enantiomeric ratios and to the synthesis of a patented indane estrogen receptor agonist with anti-cancer activity.
Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: A traceless approach to synthesize N-alkyl-2-aminobenzophenones
Wu, Yinuo,Feng, Ling-Jun,Lu, Xiao,Kwong, Fuk Yee,Luo, Hai-Bin
supporting information, p. 15352 - 15354 (2015/01/08)
A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.
Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones
Susanti, Dewi,Ng, Linda Li Ru,Chan, Philip Wai Hong
supporting information, p. 353 - 358 (2014/05/20)
2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)- mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ ethyl acetate (20:1 v/v) as the reaction medium. The utility of the approach as a potential scale-up strategy for the synthesis of 2-oxindoles was exemplified by the large-scale synthesis of one adduct in excellent yield. The synthetic applicability of this chemistry was also demonstrated by the recycling of the silica gel up to 8 times with no apparent loss of activity being observed for the same example.
New methodology for the N-alkylation of 2-amino-3-acylthiophenes
Aurelio, Luigi,Flynn, Bernard L.,Scammells, Peter J.
, p. 4886 - 4902 (2011/08/06)
2-Amino-3-acylthiophenes are known to allosterically modulate the A 1 adenosine receptor and are also used as intermediates in the synthesis of therapeutic agents and pharmacophores such as thienoazepines and thienopyrimidines. The N-alkylation
Synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed intramolecular cyanoamidation
Yasui, Yoshizumi,Kamisaki, Haruhi,Ishida, Takayuki,Takemoto, Yoshiji
supporting information; experimental part, p. 1980 - 1989 (2010/04/24)
The cyanoamidation of olefins was achieved. When N-(2-vinylphenyl)cyanoformamides were treated with palladium catalyst, intramolecular cyanoamidation took place to give corresponding 3,3-disubstituted oxindoles. P(t-Bu)3 showed a remarkable eff
