1531-38-0

Basic information

• Product Name: 1-phenyl-2-(quinolin-2-yl)ethanone
• Synonyms: 1-Phenyl-2-(quinolin-2-yl)ethanone; ethanone, 1-phenyl-2-(2-quinolinyl)-
• CAS NO: 1531-38-0
• Molecular Formula: C₁₇H₁₃NO
• Molecular Weight: 247.2912
• Mol File: 1531-38-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 410.6°C at 760 mmHg
• Flash Point: 208.4°C
• Density: 1.183g/cm³
• Vapor Pressure: 5.95E-07mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 1-phenyl-2-(quinolin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-(quinolin-2-yl)ethanone(1531-38-0)
• EPA Substance Registry System: 1-phenyl-2-(quinolin-2-yl)ethanone(1531-38-0)

Safety Data

• Hazardous Substances Data: 1531-38-0(Hazardous Substances Data)

Usage

General Description

1-phenyl-2-(quinolin-2-yl)ethanone is a chemical compound with the molecular formula C18H13NO. It is a member of the family of acetophenones and is commonly used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. It is a pale yellow crystalline solid with a distinctive floral odor and is insoluble in water but soluble in organic solvents such as ethanol and ether. The compound is also known to exhibit biological activities such as anti-inflammatory, anti-microbial, and anti-cancer properties, making it a valuable target for medicinal chemistry research. Additionally, 1-phenyl-2-(quinolin-2-yl)ethanone has applications in the field of materials science, particularly as a starting material for the synthesis of fluorescent dyes and polymers.

Upstream product

• 94463-24-8 2-(α,β-dibromo-phenethyl)-quinoline 
• 93-58-3 benzoic acid methyl ester 
• 91-63-4 2-methylquinoline 
• 613-90-1 benzoyl cyanide 
• 100-47-0 benzonitrile 
• 2005-43-8 2-bromoquinoline 
• 98-86-2 acetophenone 
• 93-89-0 benzoic acid ethyl ester 
• 1415752-94-1 1-phenyl-2-(quinolin-2-yl)ethanimine 
• 93-97-0 benzoic acid anhydride 
• 101126-37-8 (Z)-1,2-dihydro-2-benzoylmethylenequinoline 
• 70437-00-2 2-phenylethynylquinoline 
• 612-62-4 2-Chloroquinoline 

Downstream Products

• 613-53-6 2-tribromomethyl-quinoline 
• 104676-95-1 Zn((C₆H₅)CO(C₉H₆NCH))2 
• 1441704-00-2 C₃₇H₄₅LiN₂O₂ 
• 1441704-84-2 C₅₀H₄₂N₄Zn 
• 1441703-73-6 1-phenyl-2-((2-quinolyl)vinyl)-2,6-dimethylphenylamine 
• 1441703-79-2 1-phenyl-2-((2-quinolyl)vinyl)-2,6-dimethylphenylamine 
• 1417305-21-5 1,1-difluoro-3-phenyl-1H-1λ⁴,11λ⁴-[1,3,2]oxazaborinino[3,4-a]quinoline 
• 1616392-39-2 phenyl(2-phenylpyrrolo[1,2-a]quinolin-3-yl)methanone 

Relevant articles and documents

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Copper-Catalyzed Bisannulations of Malonate-Tethered O-Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues

A copper-catalyzed bisannulation reaction of malonate-tethered O-acyl oximes with pyridine, pyrazine, pyridazine, and quinoline derivatives has been developed for the concise synthesis of structurally novel dihydroindolizine-fused pyrrolidinones and their analogues. The present reaction shows excellent regioselectivity and stereoselectivity. Theoretical calculations reveal that the coordination effect of the carbonyl group in the nucleophilic substrate determines the excellent regioselectivity. Further functionalization of the generated dihydroindolizine-fused pyrrolidinone could be easily realized through substitution, Michael addition, selective aminolysis, and hydrolysis reactions.

A 1:1 type enol-pyruvyl quinazine metal complex and its synthetic method and application

The invention provides 1:1 type enol quinoline metal complexes as well as a synthetic method and application thereof. The method is characterized by using an enol quinoline coordinated ligand as a transfer reagent to react with alkylating reagents of magnesium, aluminium and zinc to synthesize a series of metal complexes. Such kind of [N,O] bidentate metal complexes can be used for catalyzing ring opening polymerization of aliphatic lactones. The method for synthesizing the complexes is simple, is lower in condition requirements and is higher in yield. The synthesized complexes have good catalytic activities and higher selectivity in ring opening polymerization of lactones. Such kind of complexes can be used for catalytically synthesizing biodegradable polyester materials.

Palladium-catalyzed mono-α-arylation of carbonyl-containing compounds with aryl halides using dalphos ligands

We report the extension and optimization of the [Pd(cinnamyl)Cl] 2/DalPhos catalyst system, previously found effective for the mono-α-arylation of acetone, to the mono-α-arylation of a variety of carbonyl-containing compounds with aryl halides and heteroaryl halides. Aryl methyl ketones, heteroaryl methyl ketones, propiophenones, malonates, and methoxyacetone can be α-arylated under relatively mild conditions and in good yields. We also report the limitations of the ligand/catalyst system towards other classes of carbonyl-containing compounds. We report the application of the [Pd(cinnamyl)Cl]2/DalPhos catalyst system, previously found effective for the mono-α-arylation of acetone, to the mono-α-arylation of a variety of carbonyl-containing compounds with aryl halides and heteroaryl halides.