153203-80-6

Basic information

• Product Name: 3,5-dichloro-4-formylbenzoic acid
• Synonyms: 3,5-dichloro-4-formylbenzoic acid
• CAS NO: 153203-80-6
• Molecular Formula: C₈H₄Cl₂O₃
• Molecular Weight: 219.02156
• Mol File: 153203-80-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 366.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.592±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
• PKA: 3.04±0.10(Predicted)
• CAS DataBase Reference: 3,5-dichloro-4-formylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloro-4-formylbenzoic acid(153203-80-6)
• EPA Substance Registry System: 3,5-dichloro-4-formylbenzoic acid(153203-80-6)

Safety Data

• Hazardous Substances Data: 153203-80-6(Hazardous Substances Data)

Usage

General Description

3,5-dichloro-4-formylbenzoic acid is a chemical compound with the molecular formula C8H4Cl2O3. It is a derivative of benzoic acid and contains two chlorine atoms, a formyl group, and a carboxylic acid functional group. 3,5-dichloro-4-formylbenzoic acid is commonly used in organic and pharmaceutical synthesis as a building block for the production of various pharmaceuticals, agrochemicals, and other industrial chemicals. It is primarily utilized as an intermediate in the production of various drugs, dyes, and perfumes. Additionally, it has been studied for its potential biological activities, including its anti-inflammatory and cytotoxic properties. Due to its versatile applications, 3,5-dichloro-4-formylbenzoic acid is a valuable chemical in the fields of chemistry and medicine.

Upstream product

• 153203-78-2 4-bromomethyl-3,5-dichlorobenzoic acid 
• 51-36-5 3,5-dichlorobenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 761-65-9 N,N-dibutylformamide 

Downstream Products

• 1465326-89-9 methyl 3,5-dichloro-4-formylbenzoate 
• 802616-47-3 2,6-dichloro-4-(methoxycarbonyl)benzoic acid 
• 1110767-89-9 3,5-dichloro-4-[(1E)-3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl]benzoic acid 
• 153203-81-7 4-formyl-3,5-dichlorobenzoyl chloride 

Relevant articles and documents

Development of manufacturing processes for the carboxylic acid key intermediate of lusutrombopag: One-pot reaction process of formylation and the horner-wadsworth-emmons reaction

We describe the development of a one-pot preparation process of (E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop- 1-en-1-yl)benzoic acid (3), which is a key carboxylic acid intermediate of lusutrombopag. This one-pot reaction process is composed of lithiation of 3,5-dichlorobenzoic acid with lithium diisopropylamide (LDA), formylation using N-formylmorpholine, followed by olefination employing the Horner-Wadsworth-Emmons reaction with triethyl 2-phosphonopropionate. This method enabled kilogram-scale manufacturing of carboxylic acid 3, a key intermediate of lusutrombopag with high purity, together with a reduced number of steps, improvement of yield, and avoidance of a cumbersome procedure for isolation of the intermediate.

A kind of the second aryl amine derivative and its preparation method, pharmaceutical composition and use thereof

The invention provides diarylamide type derivatives having a structure shown as a formula (I) as follows, or pharmaceutically acceptable salts thereof, a preparing method of the derivatives, compositions containing the derivatives and the pharmaceutically acceptable salts, and medicine uses of the derivatives and the pharmaceutically acceptable salts. The diarylamide type derivatives having the structure shown as the formula (I) or the pharmaceutically acceptable salts thereof have antagonistic effects on FXR. Integral animal experiments show that the compounds have effects of decreasing blood sugar and reducing blood fat. The compounds can be used for treating hyperlipidemia and type 2 diabetes mellitus.