153214-82-5

Basic information

• Product Name: 2,2-DIMETHOXY-PROPANE-1,3-DIOL
• Synonyms: 2,2-DIMETHOXY-PROPANE-1,3-DIOL
• CAS NO: 153214-82-5
• Molecular Formula: C₅H₁₂O₄
• Molecular Weight: 136.15
• Mol File: 153214-82-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 237.6°Cat760mmHg
• Flash Point: 97.5°C
• Appearance: /
• Density: 1.145g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.447
• CAS DataBase Reference: 2,2-DIMETHOXY-PROPANE-1,3-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHOXY-PROPANE-1,3-DIOL(153214-82-5)
• EPA Substance Registry System: 2,2-DIMETHOXY-PROPANE-1,3-DIOL(153214-82-5)

Safety Data

• Hazardous Substances Data: 153214-82-5(Hazardous Substances Data)

Usage

General Description

2,2-DIMETHOXY-PROPANE-1,3-DIOL, also known as 1,3-Dimethoxy-2-hydroxypropane, is a chemical compound with the formula C5H12O4. It is a diol, meaning it contains two hydroxyl groups (-OH) and two ether functional groups (-OCH3). 2,2-DIMETHOXY-PROPANE-1,3-DIOL is commonly used as a solvent in various chemical processes and formulations. It is a clear, colorless liquid with a sweet odor, and it is highly flammable. Its versatile properties make it useful in a variety of applications, such as in the synthesis of organic compounds and as a solvent for paints, coatings, and cleaning products. Additionally, it has potential applications in the pharmaceutical and cosmetic industries. However, it is important to handle this compound with caution due to its flammability and potential health hazards.

InChI:InChI=1/C5H12O4/c1-8-5(3-6,4-7)9-2/h6-7H,3-4H2,1-2H3

Upstream product

• 62147-49-3 1,3-dihydroxyacetone dimer 
• 149-73-5 trimethyl orthoformate 
• 96-26-4 dihydroxyacetone 
• 77-76-9 2,2-dimethoxy-propane 
• 67-56-1 methanol 

Downstream Products

• 153214-83-6 3-(allyloxy)-2,2-dimethoxypropane 
• 922500-97-8 3,3-dimethoxyoxetane 
• 869491-43-0 2,2-dimethoxypropylene carbonate 
• 115118-68-8 3,3-dimethoxycyclobutane-1,1-dicarboxylic acid diisopropyl ester 
• 174648-17-0 3-acetoxy-2,2-dimethoxypropyl dibenzyl phosphate 
• 29909-09-9 phosphoric acid mono-(3-hydroxy-2,2-dimethoxy-propyl ester) 
• 819862-89-0 3-hydroxy-2,2-dimethoxypropyl dibenzyl phosphate 
• 848470-42-8 2,2-dimethoxy-1,3-propanediol bis(p-toluenesulfonate) 
• 40166-30-1 3-(benzyloxy)-2,2-dimethoxypropan-1-ol 
• 231280-23-2 5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide 
• 191859-63-9 1,3-dibenzoxy-2-propanone methyl ketal 

Relevant articles and documents

Poly(carbonate-ester)s of dihydroxyacetone and lactic acid as potential biomaterials

The synthesis of new polymeric biomaterials using biocompatible building blocks is important for the advancement of the biomedical field. We report the synthesis of statistically random poly(carbonate-ester)s derived from lactic acid and dihydroxyacetone by ring-opening polymerization. The monomer mole feed ratio and initiator concentration were adjusted to create various copolymer ratios and molecular weights. A dimethoxy acetal protecting group was used to stabilize the dihydroxyacetone and was removed using elemental iodine and acetone at reflux to produce the final poly(lactide-co-dihydroxyacetone) copolymers. The characteristics of the copolymers in their protected and deprotected forms were characterized by 1H NMR, 13C NMR, GPC, TGA, and DSC. Hydrolytic degradation of the deprotected copolymers was tracked over an 8-week time frame. The results show that faster degradation occurred with increased carbonate content in the copolymer backbone. The degradation pattern of the copolymers was visualized using SEM and revealed a trend toward surface erosion as the primary mode of degradation.

A Three-Step Preparation of Dihydroxyacetone Phosphate Dimethyl Acetal

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Dihydroxyacetone phosphate, DHAP, in the crystalline state: monomeric and dimeric forms

It was shown that dihydroxyacetone phosphate may exist in both monomeric DHAP (C3H7O6P) and dimeric DHAP-dimer (C6H14O12P2) form. Monomeric DHAP was obtained in the form of four crystalline salts: CaCl(DHAP)·2.9H2O (7a), Ca2Cl3(DHAP)·5H2O (7b), CaCl(DHAP)·2H2O (7c), and CaBr(DHAP)·5H2O (7d) by crystallization from aqueous solutions containing DHAP acid and CaCl2 or CaBr2, or by direct crystallization from a solution containing DHAP precursor and CaCl2. At least one of the salts is stable and may be stored in the crystalline state at room temperature for several months. The dimeric form was obtained by slow saturation of free DHAP syrup with ammonia at -18 °C and isolated in the form of its hydrated diammonium salt (NH4)2(DHAP-dimer)·4H2O (8). The synthesis of the compounds, their crystallization, and crystal structures determined by X-ray crystallography are described. In all 7a-d monomeric DHAP exists in the monoanionic form in an extended (in-plane) cisoid conformation, with both hydroxyl and ester oxygen atoms being synperiplanar to the carbonyl O atom. The crucial structural feature is the coordination manner, in which the terminal phosphate oxygen atoms act as chelating as well as bridging atoms for the calcium cations. Additionally, the DHAP monoanions chelate another Ca2+ by the α-hydroxycarbonyl moiety, in a manner observed previously in dihydroxyacetone (DHA) calcium chloride complexes. In dimeric 8 the anion is a trans isomer with the dioxane ring in a chair conformation with the hydroxyl groups in axial positions and the phosphomethyl group in an equatorial position.