153391-34-5Relevant academic research and scientific papers
5-Cyanomethyl-3-(4-methylphenyl)-1-phenylpyrazole
Singh, Sanjay K.,Kumar, Ajay,Vats, Archana,Bisht, Kirpal S.,Parmar, Virinder S.,Errington, William
, p. 2404 - 2406 (1995)
The title nitrile, 3-(4-methylphenyl)-1-phenylpyrazole-5-acetonitrile, C18H15N3, is one of the products obtained from the reaction of 3-cyano-6-(4-methylphenyl)-4-methylthio-2-oxo-2H-pyran with phenylhydrazine.The asymmetric unit contains two almost identical molecules differing only in the orientations of the phenyl and methylphenyl groups with respect to the planar pyrazole nucleus.
Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants
Parmar, Virinder S.,Kumar, Ajay,Prasad, Ashok K.,Singh, Sanjay K.,Kumar, Naresh,Mukherjee, Shubhasish,Raj, Hanumantharao G.,Goel, Sanjay,Errington, William,Puar, Mohindar S.
, p. 1425 - 1436 (2007/10/03)
A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitriles did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (1H-, 13C-, 1H-1H COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. Copyright (C) 1999 Elsevier Science Ltd.
Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate
Ram, Vishnu Ji,Haque, Navedul,Singh, Sanjay Kumar,Hussaini, Falak Anwer,Shoeb, Aboo
, p. 924 - 928 (2007/10/02)
Reaction specificity of hydrazine hydrate, cyclohexyl- and phenyl-hydrazines towards 6- or 5,6-disubstituted-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and the corresponding 3-ethyl carboxylate (1,8) has been studied.
