153427-71-5Relevant academic research and scientific papers
COLLAGENASE INHIBITOR
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, (2008/06/13)
Compounds having inhibitory activity against inhibitory activity against type IV collagenase and are useful as angiogenesis, cancer infiltration or cancer metastasis inhibitors. The compounds have the formula: STR1 in which R 1 represents a group of formula:--OR. sup.3 (wherein R 3 represents a hydrogen atom or an alkyl group), --NR 4 R 5 (wherein R 4 and R 5 each represents a hydrogen atom, an alkyl or alkoxy group),--NHCH(R 6 COR 7 (wherein R 6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R 7 represents an alkyl group),--NHCH(R 6)COOR. sup.8 (wherein R 8 represents an alkyl group) or--NHCH(R 6)CONR 9 R 10 (wherein R 9 and R 10 each represents a hydrogen atom or an alkyl group, or NR 9 R 10 together represent a heterocyclic ring group); andR 2 represents a hydrogen atom, an alkyl or aralkyl group.
Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. IV. Synthesis and structure-activity relationships of matlystatin B and its stereoisomers
Tamaki,Kurihara,Oikawa,Tanzawa,Sugimura
, p. 1481 - 1492 (2007/10/02)
The first total synthesis of matlystatin B (1a), a low molecular weight inhibitor of type IV collagenases, was accomplished, and its absolute configuration was unambiguously determined. Furthermore, ten stereoisomers of 1a were synthesized, and the inhibi
Synthesis and determination of the absolute configuration of matlystatin B
Tamaki,Ogita,Tanzawa,Sugimura
, p. 683 - 686 (2007/10/02)
The title compound (1) was first synthesized and its absolute configuration was determined as shown in figure 1.
