153427-71-5

Basic information

• Product Name: Butanedioic acid, pentyl-, 1-(phenylmethyl) 4-(2,2,2-trichloroethyl) ester, (R)-
• CAS NO: 153427-71-5
• Molecular Formula: C18H23Cl3O4
• Molecular Weight: 409.737
• Mol File: 153427-71-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanedioic acid, pentyl-, 1-(phenylmethyl) 4-(2,2,2-trichloroethyl) ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanedioic acid, pentyl-, 1-(phenylmethyl) 4-(2,2,2-trichloroethyl) ester, (R)-(153427-71-5)
• EPA Substance Registry System: Butanedioic acid, pentyl-, 1-(phenylmethyl) 4-(2,2,2-trichloroethyl) ester, (R)-(153427-71-5)

Safety Data

• Hazardous Substances Data: 153427-71-5(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 147961-55-5 (4S)-4-isopropyl-3-<(2R)-2-(tert-butyloxycarbonylmethyl)-1-oxoheptyl>-2-oxazolidinone 
• 147961-56-6 tert-butyl (3R)-3-benzyloxycarbonyloctanoate 
• 153427-70-4 (3R)-3-benzyloxycarbonyloctanoic acid 
• 145588-98-3 (4S)-4-isopropyl-3-(1-oxoheptyl)-2-oxazolidinone 
• 115-20-8 1,1,1-trichloroethanol 

Downstream Products

• 3975-91-5 (R)-(+)-2-pentylsuccinic acid 
• 147961-58-8 tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-2-carboxymethyl-1-oxoheptyl>hexahydropyridazine-3-carboxylate 
• 147983-32-2 (3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxylic acid 
• 147983-31-1 tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate 
• 147983-33-3 tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxylate 
• 147961-59-9 N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide 
• 153744-15-1 N-<(1R)-1-<(1R)-1-methylpropyl>-2-oxobutyl>-(3R)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide 
• 153744-14-0 N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3R)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide 
• 153744-13-9 N-<(1R)-1-<(1R)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide 
• 153642-59-2 tert-butyl (3R)-1-benzyloxycarbonyl-2-<(2R)-2-carboxymethyl-1-oxoheptyl>hexahydropyridazine-3-carboxylate 
• 153642-61-6 (3R)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxylic acid 
• 153642-58-1 tert-butyl (3R)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate 
• 153642-60-5 tert-butyl (3R)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxylate 

Relevant articles and documents

COLLAGENASE INHIBITOR

Compounds having inhibitory activity against inhibitory activity against type IV collagenase and are useful as angiogenesis, cancer infiltration or cancer metastasis inhibitors. The compounds have the formula: STR1 in which R 1 represents a group of formula:--OR. sup.3 (wherein R 3 represents a hydrogen atom or an alkyl group), --NR 4 R 5 (wherein R 4 and R 5 each represents a hydrogen atom, an alkyl or alkoxy group),--NHCH(R 6 COR 7 (wherein R 6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R 7 represents an alkyl group),--NHCH(R 6)COOR. sup.8 (wherein R 8 represents an alkyl group) or--NHCH(R 6)CONR 9 R 10 (wherein R 9 and R 10 each represents a hydrogen atom or an alkyl group, or NR 9 R 10 together represent a heterocyclic ring group); andR 2 represents a hydrogen atom, an alkyl or aralkyl group.

Synthesis and determination of the absolute configuration of matlystatin B

The title compound (1) was first synthesized and its absolute configuration was determined as shown in figure 1.