153481-85-7

Upstream product

• 474958-86-6 (4S,5S)-2,2-dimethyl-4-phenyl-5-ethenyl[1,3]dioxolane 
• 122743-18-4 methyl (2R,3S)-2,3-dihydroxy-3-phenylpropanoate 
• 215544-03-9 (4R,5S)-ethyl 2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate 
• 103-26-4 Methyl cinnamate 
• 103-26-4 methyl cinnamate 
• 474958-70-8 (1S,2S)-2-(2-methoxy-ethoxymethoxy)-1-phenyl-but-3-en-1-ol 
• 100-52-7 benzaldehyde 
• 202589-95-5 (1S,2S)-1-phenyl-but-3-ene-1,2-diol 
• 153609-00-8 (4S,5S)-2,2-dimethyl-4-(hydroxymethyl)-5-phenyl-1,3-dioxolane 
• 153481-84-6 (4R,5S)-2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylic acid methyl ester 

Downstream Products

• 153359-62-7 (S)-((4S,5S)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-furan-2-yl-methanol 
• 556038-76-7 1-[(4R,5S)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl]-2-nitroethanol 
• 1006371-17-0 (1R)-1-[(4S,5S)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]but-3-en-1-yl prop-2-enoate 
• 474958-87-7 (1R)-1-[(4S,5S)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]but-3-en-1-ol 
• 1054624-97-3 (S)-6-((4R,5S)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-pyran-2,5-dione 
• 260354-54-9 (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-azetidin-2-one 

Relevant academic research and scientific papers

Structure-activity relationship (SAR) studies of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione: Development of potential substrate-specific ERK1/2 inhibitors

A series of analogs of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione, a putative substrate-specific ERK1/2 inhibitor, were synthesized and biologically characterized in human leukemia U937 cells to define its pharmacophore. It was disc

Ruthenium-catalyzed olefin metathesis double-bond isomerization sequence

A novel ruthenium-catalyzed tandem ring-closing metathesis (RCM) double-bond isomerization reaction is described in this paper. The utility of this method for the efficient syntheses of five-, six-, and seven-membered cyclic enol ethers is demonstrated. It relies on the conversion of a metathesis-active ruthenium carbene species to an isomerization-active ruthenium-hydride species in situ. This conversion is achieved by using various additives. Scope and limitations of the different protocols are discussed, and some mechanistic considerations based on 31P and 1H NMR spectroscopic studies are presented.

Total synthesis of the duocarmycins

The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones. Copyright

Stereoselective syntheses of (+)-goniodiol, (-)-8-epigoniodiol, and (+)-9-deoxygoniopypyrone via alkoxyallylboration and ring-closing metathesis

A convenient synthesis of (+)-goniodiol, (-)-8-epigoniodiol, and (+)-9-deoxygoniopypyrone has been developed via asymmetric alkoxyallylboration and ring-closing metathesis pathways.

On the selectivity of oxynitrilases towards α-oxygenated aldehydes

Different α-alkoxy and α,β-di-alkoxy substituted aldehydes have been submitted to the catalytic action of the oxynitrilases from almond (PaHNL) or from Hevea brasiliensis (HbHNL), in order to explore the possibility of using these enzymes for the preparation of complex cyanohydrins. The selectivity of both enzymes towards these compounds was found to be largely dependent on the substitutents, being low with the aldehydes carrying the sterically more demanding phenyl substituent. Contrary to the chemical addition of HCN, which always occurs with a slight preference for the formation of the anti diastereoisomers, the enzymatic cyanuration - occurring with a facial preference, Si or Re according to the biocatalyst used - gave a mixture of cyanohydrins that, depending on the starting enantiomeric aldehyde, can be enriched in the syn diastereoisomers.

A strategy for the asymmetric aminohomologation of α,β-dihydroxy aldehydes: Application to the synthesis of the southwest tripeptide segment of echinocandin B

The synthesis of the (2S,3S,4S)-3,4-dihydroxyhomotyrosine amino acid segment, present in echinocandin B, in its activated form ready for peptide coupling is described. The key steps of the approach are the enantioselective AD reaction of 4-methoxycinnamic

Asymmetric Total Synthesis of (+)-Goniopypyrone

An effective asymmetric total synthesis of (+)-goniopypyrone from methyl cinnamate (2) via OsO4 catalytic asymmetric dihydroxylation and highly stereoselective 2-furylcopper addition in eight steps with an overall yield of 20 percent is described.