62705-47-9

Upstream product

• 5185-54-6 2-chloro-4-phenyl-6-chloroquinazoline 
• 4797-43-7 6-chloro-4-phenylquinazolin-2-ol 
• 51483-21-7 6-chloro-4-phenylquinazoline-2-carbonitrile 
• 88190-77-6 6-chloro-3,4-dihydro-4-phenylquinazoline-2-carboxylic acid 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 67-56-1 methanol 
• 5958-08-7 6-chloro-4-phenylquinazoline-2-carboxylic acid 
• 153681-82-4 6-chloro-1,2-dihydro-4-phenylquinazoline-2-carboxylic acid 

Downstream Products

• 30739-34-5 (6-chloro-4-phenylquinazolin-2-yl)methanol 

Relevant academic research and scientific papers

4-ARYLQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A

The invention relates to certain derivatives of 4-arylquinazoline formula (I) which are inhibitors of methionine adenosyltransferase 2A (MAT2A). The invention also relates to pharmaceutical compositions comprising such compounds and methods of treating diseases that can be treated by inhibition of MAT2A such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (MTAP).

Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives

Reaction of hydroxyglycine with 2-aminobenzophenones gives 1,2-dihydro-4-phenyl-quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3,4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows the carboxylate group at C(2) and the methyl group at N(1) to be in axial positions.