5958-08-7

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-4-phenyl quinazoline-2-carboxylic acid is used as a pharmaceutical candidate for its potential anticancer properties. It is being studied for its ability to target and inhibit the growth of cancer cells, making it a promising agent in the development of cancer therapies.
Used in Drug Synthesis:
6-Chloro-4-phenyl quinazoline-2-carboxylic acid serves as a building block in the synthesis of other complex organic compounds. Its unique structure and functional groups make it a valuable component in the creation of new drugs and pharmaceuticals with diverse applications.
Used in Disease Treatment Research:
6-Chloro-4-phenyl quinazoline-2-carboxylic acid is being investigated for its potential in treating various diseases and conditions. Its biological activities are being explored to understand its therapeutic effects and possible applications in medicine.
Used in Chemical Research:
As a quinazoline derivative, 6-chloro-4-phenyl quinazoline-2-carboxylic acid is utilized in chemical research to study its properties, reactions, and potential applications in various fields, including materials science, agrochemistry, and environmental chemistry.

Upstream product

• 88190-77-6 6-chloro-3,4-dihydro-4-phenylquinazoline-2-carboxylic acid 
• 51483-21-7 6-chloro-4-phenylquinazoline-2-carbonitrile 
• 4797-43-7 6-chloro-4-phenylquinazolin-2-ol 
• 5185-54-6 2-chloro-4-phenyl-6-chloroquinazoline 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 153681-82-4 6-chloro-1,2-dihydro-4-phenylquinazoline-2-carboxylic acid 

Downstream Products

• 1373887-32-1 N-sec-butyl-6-chloro-4-phenylquinazoline-2-carboxamide 
• 1373887-33-2 N-sec-butyl-6-chloro-N-methyl-4-phenylquinazoline-2-carboxamide 
• 1373887-35-4 6-chloro-N-isopropyl-N-methyl-4-phenylquinazoline-2-carboxamide 
• 1373887-36-5 6-chloro-N,N-dihexyl-4-phenylquinazoline-2-carboxamide 
• 1373887-37-6 (6-chloro-4-phenylquinazolin-2-yl)(pyrrolidin-1-yl)methanone 
• 1373887-38-7 (6-chloro-4-phenylquinazolin-2-yl)(piperidin-1-yl)methanone 
• 1373887-39-8 azepan-1-yl(6-chloro-4-phenylquinazolin-2-yl)methanone 
• 1373887-61-6 6-chloro-N-isobutyl-4-phenylquinazoline-2-carboxamide 
• 21184-49-6 6-chloro-4-phenylquinazoline-2-carboxamide 
• 14271-32-0 6-chloro-N-methyl-4-phenylquinazoline-2-carboxamide 
• 1581275-65-1 N-benzyl-6-chloro-4-phenylquinazoline-2-carboxamide 
• 1581275-44-6 N-benzyl-6-chloro-N-ethyl-4-phenylquinazoline-2-carboxamide 
• 4015-28-5 6-chloro-4-phenylquinazoline 
• 62705-47-9 methyl 6-chloro-4-phenylquinazoline-2-carboxylate 

Relevant academic research and scientific papers

4-ARYLQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A

The invention relates to certain derivatives of 4-arylquinazoline formula (I) which are inhibitors of methionine adenosyltransferase 2A (MAT2A). The invention also relates to pharmaceutical compositions comprising such compounds and methods of treating diseases that can be treated by inhibition of MAT2A such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (MTAP).

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors

Structure-activity relationships (SARs) within the 4-phenylquinazoline-2- carboxamide series of translocator protein (TSPO) ligands have been explored further by the synthesis and TSPO binding affinity evaluation of N-benzyl-N-ethyl/methyl derivatives var

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

A series of novel 4-phenylquinazoline-2-carboxamides (1-58) were designed as aza-isosters of PK11195, the well-known 18 kDa translocator protein (TSPO) reference ligand, and synthesized by means of a very simple and efficient procedure. A number of these derivatives bind to the TSPO with Ki values in the nanomolar/subnanomolar range, show selectivity toward the central benzodiazepine receptor (BzR) and exhibit structure-affinity relationships consistent with a previously published pharmacophore/topological model of ligand-TSPO interaction.

Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives

Reaction of hydroxyglycine with 2-aminobenzophenones gives 1,2-dihydro-4-phenyl-quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3,4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows the carboxylate group at C(2) and the methyl group at N(1) to be in axial positions.