153684-40-3

Upstream product

• 5959-52-4 2-Amino-3-naphthoic acid 
• 98-88-4 benzoyl chloride 
• 348-53-8 2-fluorophenyl lithium 
• 18600-63-0 2-phenyl-4H-naphthyl<2,3-d><1,3>oxazin-4-one 
• 1072-85-1 o-fluorobromobenzene 

Downstream Products

• 154849-03-3 2--3-(2'-fluorobenzoyl)naphthalene 
• 154849-04-4 5-(2-fluorophenyl)-1,3-dihydronaphtho<2,3-e><1,4>diazepin-2-one 
• 153684-37-8 2-amino-1-(2'-fluorobenzoyl)naphthalene 

Relevant academic research and scientific papers

Synthesis of Benzo-Fused Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors

The synthesis and in vitro evaluation of benzo-fused benzodiazepines 1-6 are described.These "molecular yardsticks" were employed to probe the spatial dimensions of the lipophilic pocket L2 in the benzodiazepine receptor (BzR) cleft and to dete

The Regiospecific Synthesis Of Ortho Aminonaphthophenones Via The Addition Of Carbanions To Naphthoxazin-4-Ones

The conversion of nitronaphthalenes (see 4a and 4b) into the corresponding ortho aminonaphthylnitriles (5a and 5b) via the process of Tomioka, when combined with the addition of carbanions to the intermediate naphthoxazin-4-ones, provided a route to ortho aminonaphthophenones (7a) and (7b).These key intermediates were employed to synthesize the benzfused 2'-fluoro-1,4-benzodiazepines (1-3).