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BLU 9931 is a potent and selective inhibitor of the "aromatic amino acid hydroxylases," including phenylalanine 4-monooxygenase (PAH) and tryptophan 5-monooxygenase. These enzymes play a crucial role in the biosynthesis of neurotransmitters such as dopamine, serotonin, and noradrenaline from the amino acids phenylalanine and tyrosine. BLU 9931 is currently under investigation for its potential therapeutic applications in treating phenylketonuria (PKU) and other related metabolic disorders.

1538604-68-0

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1538604-68-0 Usage

Uses

Used in Pharmaceutical Industry:
BLU 9931 is used as a potential treatment for phenylketonuria (PKU), a rare genetic disorder characterized by a buildup of phenylalanine in the blood. This buildup can lead to intellectual disability and other serious health problems. By inhibiting the enzymes involved in phenylalanine metabolism, BLU 9931 aims to reduce the levels of phenylalanine in the blood and alleviate the symptoms associated with PKU.
Additionally, BLU 9931's ability to modulate the biosynthesis of neurotransmitters such as dopamine, serotonin, and noradrenaline may have potential applications in the treatment of various neurological and psychiatric disorders. However, further research is needed to explore these possibilities and establish the safety and efficacy of BLU 9931 in these contexts.

Check Digit Verification of cas no

The CAS Registry Mumber 1538604-68-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,8,6,0 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1538604-68:
(9*1)+(8*5)+(7*3)+(6*8)+(5*6)+(4*0)+(3*4)+(2*6)+(1*8)=180
180 % 10 = 0
So 1538604-68-0 is a valid CAS Registry Number.

1538604-68-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name BLU9931

1.2 Other means of identification

Product number -
Other names N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1538604-68-0 SDS

1538604-68-0Downstream Products

1538604-68-0Relevant academic research and scientific papers

INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR

-

, (2014/02/15)

Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.

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