1539-96-4Relevant academic research and scientific papers
A General Method for the Preparation of 1,1-Bis(Trifluoromethyl)Substituted Olefins
Lu, Hengyao,Burton, Donald J.
, p. 3973 - 3976 (1995)
The title compounds are prepared by treatment of 1,1-difluoro-2-trifluoromethyl-1-alken-3-ols (1) with diethylaminosulfur trifluoride (DAST) with high regioselectivity.The alcohols (1) are obtained by the reaction of 2-pentafluoropropenyllithium with alde
Rhenium-Catalyzed Decarboxylative Tri-/Difluoromethylation of Styrenes with Fluorinated Carboxylic Acid-Derived Hypervalent Iodine Reagents
Wang, Yin,Yang, Yunhui,Wang, Congyang
supporting information, p. 1229 - 1233 (2019/11/21)
Herein, unprecedented rhenium-catalyzed decarboxylative oxytri-/difluoromethylation and Heck-type trifluoromethylation of styrenes have been developed by using hypervalent iodine(III) reagents derived from cheap, stable, and easy-handling fluorinated carboxylic acids. Mechanistic studies revealed a radical decarboxylative trifluoromethylation pathway occurring in these reactions.
Mild and metal-free trifluoromethylation and pentafluoroethylation of gem-difluoroalkenes with TMSCF3 and TMSCF2CF3
Jin, Guanyi,Zhang, Xuxue,Fu, Dan,Dai, Wenpeng,Cao, Song
, p. 7892 - 7899 (2015/09/15)
A direct and efficient approach for the trifluoromethylation and pentafluoroethylation of 1,1-diaryl-2,2-difluoroethenes with TMSCF3 and TMSCF2CF3 in the presence of TBAF was developed. The reactions proceeded smoothly und
Direct C-H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis
Tomita, Ren,Yasu, Yusuke,Koike, Takashi,Akita, Munetaka
, p. 1099 - 1106 (2014/06/09)
Background: Trifluoromethylated alkene scaffolds are known as useful structural motifs in pharmaceuticals and agrochemicals as well as functional organic materials. But reported synthetic methods usually require multiple synthetic steps and/or exhibit lim
