153967-95-4

Upstream product

• 17100-65-1 2-bromo-4-methoxybenzoic acid methyl ester 
• 74317-85-4 2-bromo-4-methoxybenzoic acid 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 144-62-7 oxalic acid 
• 110718-87-1 1-(2-iodo-5-methoxyphenyl)ethanone 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 5446-02-6 4-methoxymethylsalicylate 
• 2237-36-7 4-methoxysalicylic acid 
• 931092-93-2 4-methoxy-2-vinylbenzoic acid methyl ester 

Downstream Products

• 931092-60-3 1-O-allyl-6-O-(4methoxy-2-vinyl-benzoyl)-2,3,4,5-tetra-O-benzyl-D-mannitol 
• 153967-87-4 N-(4-Methoxy-2-vinyl-benzoyl)-2,N-dimethyl-benzamide 
• 153967-79-4 N-methyl-3-(2-ethenyl-4-methoxyphenyl)-1(2H)-isoquinolone 
• 931092-69-2 4(R),5(R),6(R),7(R)-tetrakis(benzyloxy)-4,5,6,7,8,10-hexahydro-14-methoxy-(11E)-1H,3H-2,9-dibenzodioxacyclotetradecin-1-one 
• 153967-91-0 4-methoxy-N-methyl-2-vinylbenzamide 

Relevant academic research and scientific papers

AMINE COMPOUND FOR INHIBITING SSAO / VAP-1 AND USE THEREOF

An amine compound serving as a semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, and an application thereof in medicines that can be used for treating inflammation and/or inflammation related diseases, diabetes and/or a disease related diabetes, psychiatric disorder, ischemic disease, vascular disease, fibrosis, or tissue transplant rejection.

Palladium-catalyzed: Ortho -halogen-induced deoxygenative approach of alkyl aryl ketones to 2-vinylbenzoic acids

The 2-vinylbenzoic acids have wide applications in the field of polymer chemistry and are key precursors for the synthesis of important bioactive molecules. Herein, an ortho-halogen-induced deoxygenative approach for the generation of 2-vinylbenzoic acids from alkyl aryl ketones by palladium catalysis is discovered and explored. This approach requires no base or stoichiometric additives and can be carried out through a simple one-step process. Furthermore, the present reaction is scalable up to one-gram scale. The commercially available palladium on carbon (5 wt%) was used as a heterogeneous catalyst and showed excellent recyclability (5 times) without significant loss in catalytic activity. Pleasingly, under our optimized conditions, the alpha alkyl substituted 2-iodoacetophenones exhibit good diastereoselectivity and predominantly (E)-2-vinylbenzoic acids were obtained with good to excellent yields.

Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids

The benzomacrolactone structural motif is a privileged or evolutionarily selected scaffold that codes properties required for binding to proteins and novel analogues thereof may provide a source of new bioactive compounds. Saccharides are also privileged structures, with (amino)sugars, imino-sugars, and sugar amino acids being applied as scaffolds for the development of nonpeptidal peptidomimetics. The syntheses of novel polyhydroxylated oxamacrolides, structural analogues of natural polyketide derived macrolides, are described herein, providing a basis for their development as scaffolds. The syntheses were carried out from benzoic acids and appropriately protected D-mannitol or D-sorbitol (D-glucitol). Ring-closing metathesis was applied in the macrocyclization step with high E-alkene selectivities being observed. X-ray crystal structures, for two polyhydroxylated derivatives, show that the macrocyclic rings display similar conformations. In addition, intermolecular hydrogen-bonding networks are observed in the lattices.

A convenient synthesis of N-methyl-3-(2-ethenylphenyl)-1(2H)-isoquinolones, key models for the elaboration of the benzo[c] phenanthridinone and phenanthridine skeletons

A variety of N-methyl-3-(2-ethenylphenyl)-1(2H)-isoquinolones 1a-e have been prepared by base-induced intramolecular cyclization of N-(2-ethenylbenzoyl)-N,2-dimethylbenzamide derivatives 2a-e. The concomitant formation of the fused dihydro benzo[c]phenant