154016-47-4

Usage

Uses

Used in Pharmaceutical Industry:
(5-PHENYLISOXAZOL-3-YL)METHYLAMINE is used as a chemical intermediate for the synthesis of various pharmaceuticals and bioactive compounds. Its unique phenylisoxazole group contributes to the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
(5-PHENYLISOXAZOL-3-YL)METHYLAMINE is utilized as a research tool to study the reactivity and biological activity of isoxazole-containing molecules. This helps in understanding the compound's interactions with biological systems and its potential role in drug discovery and design.
Used in Drug Development:
(5-PHENYLISOXAZOL-3-YL)METHYLAMINE is employed as a building block in the development of new drugs, leveraging its structural features to create molecules with specific biological activities. This contributes to the advancement of novel therapeutic agents for various medical conditions.

InChI:InChI=1/C10H10N2O/c11-7-9-6-10(13-12-9)8-4-2-1-3-5-8/h1-6H,7,11H2

Upstream product

• 1619-37-0 (5-phenylisoxazol-3-yl)methanol 
• 14731-10-3 3-(chloromethyl)-5-phenylisoxazole 
• 98-86-2 acetophenone 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 154016-52-1 3-(azidomethyl)-5-phenylisoxazole 
• 154016-50-9 3-(bromomethyl)-5-phenylisoxazole 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 

Relevant academic research and scientific papers

Synthesis of 5-Arylisoxazole and 4,5-Dichloroisothiazole Amino-Substituted Derivatives and Their Biological Activity

Abstract: A series of amino derivatives of 5-arylisoxazoles and 4,5-dichloroisothiazole with primary and secondary amino groups was synthesized. 3-Aminomethyl-5-arylisoxazol-3-ylmethanamines were obtained on the basis of 5-aryl-3-(chloromethyl)isoxazoles using the Gabriel phthalimide method. 5-Arylisoxazol-3-yl- and 4,5-dichloroisothiazol-3-ylallylamines were synthesized in two ways: reduction of azomethines obtained by condensation of 5-arylisoxazolyl- and 4,5-dichloroisothiazolyl-3-carbaldehydes with allylamine, and by nucleophilic substitution of the chlorine atom in 3-chloromethyl derivatives of the corresponding azoles by reaction with allylamine. Amides and sulfonamides of azolylallylamines were synthesized. Some of the compounds obtained showed antibacterial and fungicidal activity.

NOVEL JNK INHIBITORS

Disclosed are substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines and imidazo[1,2-d]triazines compounds of the formula: (1.0) Also disclosed are methods for treating JNK1 and ERK mediated diseases using the compounds of formula 1.0.

Regioselective syntheses of 3-aminomethyl-5-substituted isoxazoles: A facile and chemoselective reduction of azide to amino by sodium borohydride using 1,3-propanedithiol as a catalyst

A series of isoxazole azides were reduced selectively to isoxazole amines in quantitative yield by sodium borohydride using 1,3-propanedithiol as a catalyst.