154016-50-9

Usage

Uses

Used in Medicinal Chemistry:
Isoxazole, 3-(bromomethyl)-5-phenylis utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Pharmaceutical Development:
Isoxazole, 3-(bromomethyl)-5-phenylplays a crucial role in the creation of novel pharmaceuticals, particularly those targeting specific diseases or conditions. Its presence in drug molecules can enhance their efficacy, selectivity, and overall therapeutic potential.
Used in Agrochemicals:
Isoxazole, 3-(bromomethyl)-5-phenylis also employed in the development of agrochemicals, such as pesticides and herbicides. Its incorporation into these products can improve their effectiveness in controlling pests and weeds, thereby benefiting agricultural practices.
Used in Organic Synthesis:
As an intermediate in organic synthesis processes, Isoxazole, 3-(bromomethyl)-5-phenylfacilitates the production of a wide range of chemical compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of various organic molecules.
Used in Chemical Research:
Due to its potential biological activity, Isoxazole, 3-(bromomethyl)-5-phenylserves as a useful tool in chemical research. It can be employed to study various biological processes and interactions, contributing to a deeper understanding of chemical and biological phenomena.

Upstream product

• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 98-86-2 acetophenone 
• 51677-09-9 methyl 5-phenylisoxazole-3-carboxylate 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 1619-37-0 (5-phenylisoxazol-3-yl)methanol 

Downstream Products

• 154016-52-1 3-(azidomethyl)-5-phenylisoxazole 
• 154016-47-4 (5-phenyl-isoxazol-3-yl)methylamine 
• 934603-40-4 Methyl 3-(6-aminopyridin-3-yl)-2-[1-(5-phenylisoxazol-3-ylmethyl)-1H-imidazol-4-yl]propionate 
• 1352576-28-3 Br^(1-)*C₃₁H₃₈N₃O₃⁽¹⁺⁾ 

Relevant academic research and scientific papers

Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies

The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing the 150-cavity which is nascent to the activity site of NA. NA inhibitory studies showed that new derivatives demonstrated the inhibitory activity with IC50 values at nM level against NA of a clinical influenza virus strain. Moreover, the in silico ADME predictions showed that the selected compounds had comparable properties with oseltamivir carboxylate, which demonstrated the druggablity of these derivatives. Furthermore, molecular docking studies showed that the most potent compound 6f and 10i could adopt different modes of binding interaction with NA, which may provide novel solutions for treating oseltamivir-resistant influenza. Based on the research results, we consider that compounds 6f and 10i have the potential for further studies as novel antiviral agents.

Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents

In our endeavour towards the development of effective anticancer therapeutics, a novel series of isoxazole-piperazine hybrids were synthesized and evaluated for their cytotoxic activities against human liver (Huh7 and Mahlavu) and breast (MCF-7) cancer ce

Regioselective syntheses of 3-aminomethyl-5-substituted isoxazoles: A facile and chemoselective reduction of azide to amino by sodium borohydride using 1,3-propanedithiol as a catalyst

A series of isoxazole azides were reduced selectively to isoxazole amines in quantitative yield by sodium borohydride using 1,3-propanedithiol as a catalyst.