15410-83-0

Basic information

• Product Name: 2-(naphthalen-2-yl)butanoic acid
• CAS NO: 15410-83-0
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.2598
• Mol File: 15410-83-0.mol

Chemical Properties

• Boiling Point: 378.8°C at 760 mmHg
• Flash Point: 275.6°C
• Density: 1.159g/cm³
• Vapor Pressure: 2.06E-06mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 2-(naphthalen-2-yl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(naphthalen-2-yl)butanoic acid(15410-83-0)
• EPA Substance Registry System: 2-(naphthalen-2-yl)butanoic acid(15410-83-0)

Safety Data

• Hazardous Substances Data: 15410-83-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(naphthalen-2-yl)butanoic acid is utilized as a building block for the synthesis of a variety of drugs and pharmaceutical intermediates. Its structural features make it a valuable component in the development of new therapeutic agents.
Used in Anti-inflammatory and Analgesic Applications:
2-(naphthalen-2-yl)butanoic acid is studied for its potential anti-inflammatory and analgesic properties, indicating its use as a therapeutic agent for conditions involving inflammation and pain.
Used in Neurological Disorder Treatment:
2-(naphthalen-2-yl)butanoic acid has been investigated for its potential role in the treatment of neurological disorders, suggesting its use as a neuroprotective or therapeutic agent in this medical field.
Used as a Bioactive Compound:
2-(naphthalen-2-yl)butanoic acid is also recognized for its potential as a bioactive compound, which implies its use in research and development for discovering new biological activities and applications in medicine and other industries.

Upstream product

• 75-03-6 ethyl iodide 
• 581-96-4 2-naphthylacetic acid 
• 2489-87-4 2-allylnaphthalene 
• 32316-92-0 naphthalene-2-boronic acid 
• 580-13-2 2-bromonaphthalene 
• 85287-67-8 2,2,6,6-tetramethyl-4-propylidene-3,5-dioxa-2,6-disilaheptane 

Relevant articles and documents

Photoinduced Copper-Catalyzed Asymmetric Decarboxylative Alkynylation with Terminal Alkynes

We describe a photoinduced copper-catalyzed asymmetric radical decarboxylative alkynylation of bench-stable N-hydroxyphthalimide(NHP)-type esters of racemic alkyl carboxylic acids with terminal alkynes, which provides a flexible platform for the construction of chiral C(sp3)?C(sp) bonds. Critical to the success of this process are not only the use of the copper catalyst as a dual photo- and cross-coupling catalyst but also tuning of the NHP-type esters to inhibit the facile homodimerization of the alkyl radical and terminal alkyne, respectively. Owing to the use of stable and easily available NHP-type esters, the reaction features a broader substrate scope compared with reactions using the alkyl halide counterparts, covering (hetero)benzyl-, allyl-, and aminocarbonyl-substituted carboxylic acid derivatives, and (hetero)aryl and alkyl as well as silyl alkynes, thus providing a vital complementary approach to the previously reported method.

Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy

A novel traceless protecting strategy is presented for the long-standing challenge of conducting the palladium-catalyzed α-arylation of carboxylic aids and secondary amides with aryl halides. Both of the presented coupling processes occur with a variety of carboxylic acids and amides and with a variety of aryl bromides containing a broad range of functional groups, including base-sensitive functionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups. Five commercial drugs were prepared through this method in one step in 81-96% yield. Gram-scale synthesis of medication Naproxen and Flurbiprofen with low palladium loading further highlights the practical value of this method.

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries

A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable.