2-(naphthalen-2-yl)butanoic acid

Base Information

• Chemical Name: 2-(naphthalen-2-yl)butanoic acid
• CAS No.: 15410-83-0
• Molecular Formula: C14H14 O2
• Molecular Weight: 214.2598
• Mol file: 15410-83-0.mol

Synonyms:2-(2-Naphthyl)butanoicacid

Chemical Property of 2-(naphthalen-2-yl)butanoic acid

Chemical Property:

• Vapor Pressure: 2.06E-06mmHg at 25°C
• Boiling Point: 378.8°Cat760mmHg
• Flash Point: 275.6°C
• Density: 1.159g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(naphthalen-2-yl)butanoic acid

There total 6 articles about 2-(naphthalen-2-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-allylnaphthalene (2489-87-4) + benzene-1,3,5-triyl triformate → 2-(naphthalen-2-yl)butanoic acid (15410-83-0)

Guidance literature:

With formic acid; palladium diacetate; triphenylphosphine; In toluene; at 100 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02047

Reference yield:

2-allylnaphthalene (2489-87-4) + benzene-1,3,5-triyl triformate → 4-(2-naphthyl)butyric acid (782-28-5) + 2-(naphthalen-2-yl)butanoic acid (15410-83-0) + 2-methyl-3-naphthalen-2-ylpropionic acid (107777-19-5)

Guidance literature:

With formic acid; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 100 ℃; Overall yield = 67 %; Overall yield = 45.7 mg; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02047

Reference yield:

ethyl iodide (75-03-6) + 2-naphthylacetic acid (581-96-4) → 2-(naphthalen-2-yl)butanoic acid (15410-83-0)

Guidance literature:

2-naphthylacetic acid; With n-butyllithium; In tetrahydrofuran; hexanes; at 0 ℃; for 0.166667h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; hexanes; Inert atmosphere;

DOI:10.1021/ja205107x

upstream raw materials:

ethyl iodide

2-naphthylacetic acid

2-allylnaphthalene

naphthalene-2-boronic acid

Refernces

• 1、 Wu, Fu-Peng,Li, Da,Peng, Jin-Bao,Wu, Xiao-Feng. "Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals". supporting information. p. 5699 - 5703. Retrieved 2019/08/01.
• 2、 Stivala, Craig E.,Zakarian, Armen. "Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries". supporting information; experimental part. p. 11936 - 11939. Retrieved 2011/09/19.