154109-07-6

Upstream product

• 19957-18-7 diethyl 4-fluorobenzoylphosphonate 
• 67-56-1 methanol 
• 100-46-9 benzylamine 
• 403-43-0 4-fluorobenzoyl chloride 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 1206515-58-3 diethyl N-(4-tolylsulfonyl)-4-fluorobenzimidoylphosphonate 
• 1206515-54-9 diethyl (E)-N-(4-chlorobenzoyloxy)-4-fluorobenzimidoylphosphonate 
• 1206515-52-7 diethyl (E)-N-(4-nitrobenzoyloxy)-4-fluorobenzimidoylphosphonate 
• 1206515-56-1 diethyl (E)-N-(3,4-dichlorophenylcarbamoyloxy)-4-fluorobenzimidoylphosphonate 
• 181259-74-5 diethyl (E)-[N-(hydroxy)imino](p-fluorophenyl)methylphosphonate 
• 125553-06-2 α-amino-(4'-fluorophenyl-)methanephosphonic acid 
• 154109-23-6 [(4-Fluoro-phenyl)-hydroxyamino-methyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Palladium-catalyzed asymmetric hydrogenation of N-hydroxya-imino phosphonates using bronsted acid as activator: The first catalytic enantioselective approach to chiral N-hydroxy-aamino phosphonates

The enantioselective synthesis of ring-substituted [N-(hydroxy)amino] ACHTUNGTRENUNG(phenyl)methylphos- ACHTUNGTRENUNGphonic esters via asymmetric hydrogenation of the corresponding N-hydroxy-a-imino phosphonates with up to 90% ee was developed using cata

α-Hydroxy- and (α-acyloxyimino)benzylphosphonates

N-Hydroxyfluorobenzimidoylphosphonates and their O-acyl derivatives are synthesized. Reaction of phosphorylated oximes with sulfinyl chloride proceeds with rearrangement and leads to synthetically prospective N- sulfonylimidoylphosphonates. By the method

The preparation and characterization of some fluorinated α-aminoarylmethanephosphonic acids

α-Aminoarylmethanephosphonic acids have been prepared with a range of fluoro, fluoroalkyl, or fluoroalkoxy substituents in the benzene ring (4-F, 3-F, 2-F, 3,4-F2, F5, 4-CF3, 3-CF3, 4-CF3O, and 3-CF3O). These compounds have relatively low aqueous solubility and their NMR spectra (1H, 13C, 31P and 19F) were therefore recorded in D2O in the presence of an excess of alkali. Under these conditions, the ring substituents appear to have little effect on δp (15-18 ppm), or on the 1H and 13C parameters for the benzylic group (α-CH), which are mainly in the ranges observed for other types of α-aminoarylmethanephosphonic acids under alkaline conditions (δH 3.8-4.0 ppm, 2JPH 15.3-16.5 Hz; δC 57-58 ppm, 1JPC 128-132 Hz). For those examples with fluorine in the ortho position (i.e., the 2-fluoro and pentafluoro derivatives) a slightly higher field chemical shift was observed for the benzylic carbon atom (δC 50-51 ppm). In the fast-atom bombardment mass spectra, pseudo-molecular ions, MH+, and ions resulting from the elimination of phosphorous acid [MH - H3PO3]+, provide a further useful means of chararacterization for these compounds. Key words: Fluorinated aminoarylmethanephosphonic acids, dialkyl N-diphenylmethylaminoaryl-methanephosphonates, NMR spectroscopy, FAB mass spectrometry.

Studies on organophosphorus compounds; LXXV: A facile synthesis of 1-(hydroxyamino)alkyl(or aryl)phosphonic acids

Reduction of dialkyl 1-(hydroxyimino)alkyl(aryl)phosphonate 1 with borane-pyridine complex proceeds smoothly to give dialkyl 1-(hydroxyamino)alkyl(or aryl)phosphonate 2 which is then easily converted into the corresponding hydroxyaminophosphonic acid 3 by