15433-79-1

Basic information

• Product Name: 5-[(DIMETHYLAMINO)METHYL]-2-FURANMETHANOL
• Synonyms: 5-[(DIMETHYLAMINO)METHYL]-2-FURANMETHANOL;5-[(dimethylamino)methyl]furan-2-methanol;5-Dimethylaminomethyl-2-furfuryl alcohol;Einecs 239-445-2;2-FuranMethanol, 5-[(diMethylaMino)Methyl]-;(5-((diMethylaMino)Methyl)furan-2-yl)Methanol
• CAS NO: 15433-79-1
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19
• EINECS: 239-445-2
• Mol File: 15433-79-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 217.7°Cat760mmHg
• Flash Point: 85.5°C
• Appearance: /
• Density: 1.088g/cm³
• Vapor Pressure: 0.0762mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 14.02±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 5-[(DIMETHYLAMINO)METHYL]-2-FURANMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(DIMETHYLAMINO)METHYL]-2-FURANMETHANOL(15433-79-1)
• EPA Substance Registry System: 5-[(DIMETHYLAMINO)METHYL]-2-FURANMETHANOL(15433-79-1)

Safety Data

• Hazardous Substances Data: 15433-79-1(Hazardous Substances Data)

Usage

Uses

5-[(Dimethylamino)methyl]-2-furanmethanol is an intermediate in the synthesis of Ranitidine hydrochloride (R120000). 5-[(Dimethylamino)methyl]-2-furanmethanol is an inhibitor of monoamine oxidase B.

InChI:InChI=1/C8H13NO2/c1-9(2)5-7-3-4-8(6-10)11-7/h3-4,10H,5-6H2,1-2H3

Upstream product

• 98-00-0 (2-furyl)methyl alcohol 
• 506-59-2 N,N-dimethylammonium chloride 
• 74626-24-7 methyl 5-dimethylaminomethyl-2-furoate 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 57-48-7 D-Fructose 
• 68-12-2 N,N-dimethyl-formamide 
• 158687-88-8 (5-Methoxymethyl-furan-2-ylmethyl)-dimethyl-amine 
• 66357-35-5 ranitidine hydrochloride 
• 66357-59-3 ranitidine hydrochloride 
• 51-80-9 bis-(dimethylamino)methane 

Downstream Products

• 66473-26-5 5-hydroxymethylfurfuryltrimethylammonium iodide 
• 80646-14-6 <(5-dimethylaminomethyl)-2-furyl>methanethiol 
• 66356-53-4 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine 
• 15433-83-7 5-<(dimethylamino)methyl>furfural 

Relevant articles and documents

Synthesis of highly fluorescent and water soluble perylene bisimide

Designed and synthesized a new highly water soluble N,N′-bis(2-((5- ((dimethylamino)methyl)furan-2-yl)methylthio)ethyl)perylene-3,4,9, 10-tetracarboxylic diimide from 2-((5-((dimethylamino)methyl)furan-2-yl) methylthio)ethanamine and perylene-3,4,9,10-tetracarboxylic dianhydride. The compound was characterized by 1H, 13C, 2D NMR, mass and IR techniques. The compound is highly fluorescent with good solubility in water and other polar solvents.

Reductive Amination, Hydrogenation and Hydrodeoxygenation of 5-Hydroxymethylfurfural using Silica-supported Cobalt- Nanoparticles

Efficient and selective conversion of renewable feedstocks to essential chemicals and fuels applying green and sustainable catalytic processes is of central importance and attracts scientific interest. Among different biomass-based feedstocks, 5-hydroxymethylfurfural (HMF) represents valuable platform compound widely used for the synthesis of valuable chemicals, fuels, and polymers. Here we report cobalt nanoparticles catalyzed reductive amination, hydrogenation and hydrodeoxygenation of HMF to produce furan based primary, secondary and tertiary amines including N-methylamines as well as 2,5-bis(hydroxymethyl)furan, (5-methylfuran-2-yl)methanol and selected N-, O-, and S-containing heterocycles. Key to success for this HMF valorization is the use of reusable silica supported cobalt-based nanoparticles, which have been prepared by the immobilization and pyrolysis of Co-terephthalic acid-piperazine MOF template on silica.

4 β-nitrogen substituted [...] amine podophyllotoxin derivative and its preparation method and application

The invention provides a 4beta-nitrogen-substituted furan tertiary amine podophyllotoxin derivative. The structural general formula of the derivative is as shown in the specification. The compound is good in solubility and strong in anti-tumor activity and has an obvious suppression effect on the tumor cells such as lung cancer, malignant lymphoma, acute leukemia and the like. The invention also provides a preparation method of the compound.