154387-90-3Relevant academic research and scientific papers
Nano indium oxide-catalyzed domino reaction for the synthesis of N-alkoxylated benzimidazoles
Samanta, Satyajit,Mahato, Sachinta,Chatterjee, Rana,Santra, Sougata,Zyryanov, Grigory V.,Majee, Adinath
supporting information, (2020/07/20)
A convenient method has been developed for the selective synthesis of N-alkoxylated benzimidazole derivatives by the cyclocondensation reaction of simple ortho-phenylenediamine, formaldehyde and alcohols in presence of indium oxide nanoparticles as catalyst. The alcohol acts as reactant as well as solvent in this reaction. No other solvents or additives have been used for this reaction. The catalyst can be reused several times without significant loss of catalytic activity. A probable reaction mechanism has been proposed based on some control experiments.
A Facile and efficient procedure for the synthesis of new benzimidazole-2-thione derivatives
Rivera, Augusto,Maldonado, Mauricio,Rios-Motta, Jaime
experimental part, p. 8578 - 8586 (2012/10/07)
A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]- [1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, 1H-, 13C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%-51.4% yield.
1-ALKOXYMETHYL- AND 1-ALKYLTHIOMETHYL-4-DIMETHYLAMINOPYRIDINIUM CHLORIDES
Pernak, Juliusz,Michalak, Lucyna
, p. 311 - 322 (2007/10/02)
ROCH2Cl or RSCH2Cl reacts with DMAP to form stable pyridinium chlorides.Reaction of these chlorides with NaOH produces the corresponding 4-pyridones.N-Alkoxymethylation of a free NH group of azoles is developed from 1-alkoxymethyl-4-dimethylaminopyridiniu
