154409-68-4Relevant academic research and scientific papers
A highly selective protocol for the deprotection of BOC-protected amides and carbamates
Stafford, Jeffrey A.,Brackeen, Marcus F.,Karanewsky, Donald S.,Valvano, Nicole L.
, p. 7873 - 7876 (1993)
A BOC-protected amide or carbamate undergoes mild and selective deprotection by treatment with catalytic Mg(ClO4)2 in acetonitrile. Simple BOC-protected amines are not affected by these conditions.
Expanding the scope and orthogonality of PNA synthesis
Pothukanuri, Srinivasu,Pianowski, Zbigniew,Winssinger, Nicolas
supporting information; experimental part, p. 3141 - 3148 (2009/05/27)
Peptide nucleic acids (PNAs) hybridize to natural oligonucleotides according to Watson and Crick base-pairing rules. The robustness of PNA oligomers and ease of synthesis have made them an attractive platform to encode small or macromolecules for microarr
Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases
Debaene, Fran?ois,Da Silva, Julien A.,Pianowski, Zbigniew,Duran, Fernando J.,Winssinger, Nicolas
, p. 6577 - 6586 (2008/02/05)
Seven PNA-encoded combinatorial libraries targeting proteases and phosphatases with covalent reversible and irreversible mechanism-based inhibitors were prepared. The libraries were synthesized using modified PNA monomers, which dramatically increase the water solubility of the libraries in biologically relevant buffers. The libraries were shown to selectively inhibit targeted enzymes.
