A highly selective protocol for the deprotection of BOC-protected amides and carbamates

DOI: 10.1016/S0040-4039(00)61498-3

Source and publish data:

Tetrahedron Letters p. 7873 - 7876 (1993)

Update date:2022-08-03

Topics:

Authors:

Stafford, Jeffrey A.

Brackeen, Marcus F.

Karanewsky, Donald S.

Valvano, Nicole L.

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Article abstract of DOI:10.1016/S0040-4039(00)61498-3

A BOC-protected amide or carbamate undergoes mild and selective deprotection by treatment with catalytic Mg(ClO₄)₂ in acetonitrile. Simple BOC-protected amines are not affected by these conditions.

Full text of DOI:10.1016/S0040-4039(00)61498-3

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