211321-08-3

Upstream product

• 71-30-7 Cytosine 
• 5437-45-6 Benzyl bromoacetate 

Downstream Products

• 623145-62-0 benzyl (4-N-(benzhydryloxycarbonyl)cytosine)-1-acetate 
• 945606-71-3 C₂₁H₂₇O₆N₅ 
• 154409-68-4 benzyl cytosine(Boc) acetate 
• 186046-78-6 [4-N-(benzhydryloxycarbonyl)cytosin-1-yl]acetic acid 
• 1052676-68-2 benzyl cytosine(4-MeOCbz) acetate 
• 1052676-66-0 benzyl cytosine(F-Bhoc) acetate 
• 1052676-65-9 benzyl cytosine(Cl-Bhoc) acetate 
• 1052676-71-7 benzyl cytosine(Teoc) acetate 
• 623145-66-4 (1-{[(2-azido-ethyl)-(benzylcarbamoyl-methyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzhydryl ester 
• 623145-46-0 benzyl N-(2-azidoethyl)-N-[4-N-(benzhydryloxycarbonyl)cytosine-1-acetyl]glycinate 
• 623145-54-0 N-(2-azidoethyl)-N-[4-N-(benzhydryloxycarbonyl)cytosine-1-acetyl]glycine 
• 172405-16-2 {4-[(tert-butoxycarbonyl)amino]-2-oxopyrimidin-1(2H)-yl}acetic acid 

Relevant academic research and scientific papers

Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

(Equation presented) A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the pho

Nucleic acid medicine delivery system and application thereof

The invention discloses a nucleic acid medicine delivery system and application thereof. The system consists of a neutral base lipid carrier and metal salt, wherein the structure of the neutral base lipid carrier is shown as a formula I. In addition, the delivery system provided by the invention also comprises metal salt. The experiment proves that through the existence of metal ion, the silent activity of the nucleic acid medicine can be effectively improved; the effective transportation of the nucleic acid medicine in the cells and in the body can be realized. The chemical modification methods such as D,L-isonucleoside modification, deoxyinosine modification, peptide conjugation modification and phosphorylation modification are jointly used for nucleic acid delivery system study; the advantages and rules of the nucleic acid delivery in a composite modification mode are sufficiently explored; the modification strategies are used in the nucleic acid medicine study. Study proves that the products obtained through chemical modification are more applicable to the system; in addition, the advantages of stable physicochemical properties, good bioactivity and good membrane permeability and the like are realized. The nucleic acid medicine delivery system provided by the invention has wide application prospects in the gene treatment field. The formula is shown in the description.

Expanding the scope and orthogonality of PNA synthesis

Peptide nucleic acids (PNAs) hybridize to natural oligonucleotides according to Watson and Crick base-pairing rules. The robustness of PNA oligomers and ease of synthesis have made them an attractive platform to encode small or macromolecules for microarr

A method for the preparation of nucleic acid binding compound

A method of the preparation of a nucleic acid binding compound is disclosed wherein a first protecting group removable by a medium strong base and a second protecting group removable by a medium strong acid are used. The synthesis is thereby is increased in recovery yield of a nucleic acid binding compound prepared.