154419-39-3Relevant academic research and scientific papers
New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein
Stevenson, Louise,Tavares, Adriana A.S.,Brunet, Aurelie,McGonagle, Fiona I.,Dewar, Deborah,Pimlott, Sally L.,Sutherland, Andrew
supporting information; experimental part, p. 954 - 957 (2010/06/11)
With the aim of developing new SPECT imaging agents for the translocator protein (TSPO), a small library of iodinated quinoline-2-carboxamides have been prepared and tested for binding affinity with TSPO. N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity (Ki 12.0 nM), comparable to that of the widely used TSPO imaging agent PK11195.
SYNTHESIS OF 2-SUBSTITUTED 2,3-DIHYDRO-9-PHENYL-1H-PYRROLOQUINOLIN-3-ONES AS POTENTIAL PERIPHERAL BENZODIAZEPINE-RECEPTOR LIGANDS
Anzini, Maurizio,Capelli, Andrea,Vomero, Salvatore
, p. 103 - 112 (2007/10/02)
Two synthetic routes to the achievement of the title compounds are described. 2-Chloromethyl-3-ethoxycarbonyl-4-phenylquinoline (4) was transformed into the corresponding lacton (5) which in two steps was converted into its isomeric lacton (7).Aminolysis
