154419-32-6

Basic information

• Product Name: Furo[3,4-b]quinolin-3(1H)-one, 9-phenyl-
• CAS NO: 154419-32-6
• Molecular Formula: C17H11NO2
• Molecular Weight: 261.28
• Mol File: 154419-32-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Furo[3,4-b]quinolin-3(1H)-one, 9-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,4-b]quinolin-3(1H)-one, 9-phenyl-(154419-32-6)
• EPA Substance Registry System: Furo[3,4-b]quinolin-3(1H)-one, 9-phenyl-(154419-32-6)

Safety Data

• Hazardous Substances Data: 154419-32-6(Hazardous Substances Data)

Upstream product

• 85422-43-1 9-phenylfuro[3,4-b]quinoline-1(3H)-one 
• 17282-95-0 diethyl 4-phenylquinoline-2,3-dicarboxylate 
• 36796-96-0 2-benzyl-9-phenyl-1,2-dihydro-3H-pyrrolo[3,4-b]quinolin-3-one 
• 62-53-3 aniline 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 154419-40-6 ethyl 4-phenyl-3-methylquinoline-2-carboxylate 
• 154419-39-3 4-phenyl-3-methylquinoline-2-carboxylic acid 
• 126334-84-7 ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate 
• 154419-41-7 3-bromomethyl-2-ethoxycarbonyl-4-phenylquinoline 
• 154419-31-5 2,3-bis(hydroxymethyl)-4-phenylquinoline 

Downstream Products

• 154419-34-8 N-benzyl-3-chloromethyl-4-phenylquinoline-2-carboxamide 
• 36796-96-0 2-benzyl-9-phenyl-1,2-dihydro-3H-pyrrolo[3,4-b]quinolin-3-one 
• 1217189-49-5 3-hydroxymethyl-N-methyl-N-phenethyl-4-phenylquinoline-2-carboxamide 
• 342011-77-2 N,N-diethyl-3-hydroxymethyl-4-phenylquinoline-2-carboxamide 
• 596819-58-8 3-chloromethyl-4-phenyl-quinoline-2-carboxylic acid benzyl-methyl-amide 
• 596819-57-7 N-benzyl-3-hydroxymethyl-N-methyl-4-phenylquinoline-2-carboxamide 
• 154419-33-7 N-benzyl-3-hydroxymethyl-4-phenylquinoline-2-carboxamide 

Relevant articles and documents

Oxone promoted dehydrogenative Povarov cyclization of: N -aryl glycine derivatives: An approach towards quinoline fused lactones and lactams

Oxone promoted intramolecular dehydrogenative imino Diels-Alder reaction (Povarov cyclization) of alkyne tethered N-aryl glycine esters and amides has been explored, thus affording biologically significant quinoline fused lactones and lactams. The reaction is simple, scalable, and high yielding (up to 88%). The method was further extended to prepare biologically important luotonin-A analogues and the quinoline core of uncialamycin.

Radical cation salt-promoted catalytic aerobic sp3 C-H oxidation: Construction of quinoline-fused lactones and lactams

A direct construction of quinoline-fused lactones and lactams was achieved by sp3 C-H bond oxidation of N-aryl glycine esters and amides under catalytic radical cation salt-induced conditions. These polycyclic products are formed in a single step from readily accessible starting materials, and this method provides a new synthetic approach to this class of heterocycles.

New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein

With the aim of developing new SPECT imaging agents for the translocator protein (TSPO), a small library of iodinated quinoline-2-carboxamides have been prepared and tested for binding affinity with TSPO. N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity (Ki 12.0 nM), comparable to that of the widely used TSPO imaging agent PK11195.