154479-32-0Relevant academic research and scientific papers
Direct conversion of secondary propargyl alcohols into 1,3-di-arylpropanoneviaDBU promoted redox isomerization and palladium assisted chemoselective hydrogenation in a single pot operation
Bera, Mrinal K.,Chandra, Shubhadeep,De, Rimpa,Savarimuthu, S. Antony
, p. 17871 - 17877 (2021/10/12)
Palladium(ii)acetate is found to be an efficient catalyst for the single-step conversion of secondary propargyl alcohols to 1,3-diarylpropanone derivatives under mild basic conditions. The reaction is believed to proceedviaredox isomerisation of secondary propargyl alcohols followed by chemoselective reduction of an enone double bond with formic acid as an adequate hydrogen donor. A large number of 1,3-diarylpropanone derivatives may readily be prepared from a milligram to a multigram scale.
Selective catalytic synthesis of α-alkylated ketones and β-disubstituted ketones via acceptorless dehydrogenative cross-coupling of alcohols
Bhattacharyya, Dipanjan,Sarmah, Bikash Kumar,Nandi, Sekhar,Srivastava, Hemant Kumar,Das, Animesh
supporting information, p. 869 - 875 (2021/02/06)
Herein, a phosphine-free pincer ruthenium(III) catalyzed β-alkylation of secondary alcohols with primary alcohols to α-alkylated ketones and two different secondary alcohols to β-branched ketones are reported. Notably, this transformation is environmentally benign and atom efficient with H2O and H2 gas as the only byproducts. The protocol is extended to gram-scale reaction and for functionalization of complex vitamin E and cholesterol derivatives.
Photoredox-Catalyzed Hydroacylation of Olefins Employing Carboxylic Acids and Hydrosilanes
Zhang, Muliang,Ruzi, Rehanguli,Xi, Junwei,Li, Nan,Wu, Zhongkai,Li, Weipeng,Yu, Shouyun,Zhu, Chengjian
supporting information, p. 3430 - 3433 (2017/07/15)
A hydroacylation reaction of alkenes has been achieved employing readily available carboxylic acids as the acyl source and hydrosilanes as a hydrogen source via photoredox catalysis. The combination of both single electron transfer and hydrogen atom transfer steps has dramatically expanded new applications of carboxylic acids in organic synthesis. The protocol also features extremely mild conditions, broad substrate scope, and good functional group tolerance, affording a novel and convenient approach to hydroacylation of alkenes.
Palladium on graphene: The in situ generation of a catalyst for the chemoselective reduction of α,β-unsaturated carbonyl compounds
Morimoto, Naoki,Yamamoto, Shun-Ichi,Takeuchi, Yasuo,Nishina, Yuta
, p. 15608 - 15612 (2013/09/12)
Palladium-supported graphene oxide has been successfully applied as a catalyst precursor for the selective reduction of α,β-unsaturated carbonyl compounds. Pd nanoparticles were formed during the course of the reduction with only negligible leaching of the Pd species into the reaction mixture.
Synthesis of 2-(4-halogenobenzyl)-3-arylbenzothiophenes and a 2-(4-fluorobenzyl)-3-arylbenzoselenophene as Selective Ligands for Antiestrogen-Binding Sites
Zhu, Ji,Srikanth, Natarajan,Ng, Siu-Choon,Kon, Oi-Lian,Sim, Keng-Yoow
, p. 672 - 682 (2007/10/02)
Several basic ethers of 2-halogenobenzyl-3-arylbenzothiophenes and a 2-(4-fluorobenzyl)-3-arylbenzoselenophene have been synthesized in good yields in a 5-step sequence from the readily available corresponding chalcones.The key step in the synthesis
