3197-44-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-Piperidin-2-ylMethanol is used as a key intermediate in the synthesis of various pharmaceutical compounds, such as antihistamines and antipsychotic drugs, due to its unique structural features and pharmacological properties.
Used in Medicinal Chemistry:
(R)-Piperidin-2-ylMethanol serves as a building block for the preparation of various organic molecules and bioactive substances, contributing to the development of new drugs and therapeutic agents in medicinal chemistry.
Used in Drug Development:
(R)-Piperidin-2-ylMethanol's potential applications in drug development are attributed to its ability to enhance the pharmacological properties of synthesized drugs, making it a valuable asset in the creation of novel therapeutic agents.

InChI:InChI=1/C6H13NO/c8-5-6-3-1-2-4-7-6/h6-8H,1-5H2/t6-/m0/s1

Upstream product

• 35677-83-9 (+)-2R-Piperidine-2-carboxylic acid methyl ester 
• 141-78-6 ethyl acetate 
• 3433-37-2 piperidin-2-ylmethanol 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 154499-13-5 benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 4043-87-2 pipecolic Acid 
• 160885-25-6 (2R,3R,4S)-1-benzyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-aziridine-2-carboxylic acid ethyl ester 
• 189188-59-8 (2R,3R)-ethyl 1-benzyl-3-((S)-1,2-dihydroxyethyl)aziridine-2-carboxylate 
• 1353042-37-1 (R)-ethyl 6-oxopiperidine-2-carboxylate 
• 182969-96-6 (Z)/(E)-ethyl 3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-bromo-2-propenoate 
• 60343-64-8 (R)-(1-tosylpiperidin-2-yl)methanol 
• 107970-42-3 N-(hepta-5,6-dien-1-yl)-4-methylbenzenesulfonamide 
• 928-90-5 5-hexyl-1-ol 
• 73229-30-8 hepta-5,6-diene-1-ol 

Downstream Products

• 134441-61-5 tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 539823-49-9 (R)-2-hydroxymethyl-1-(2-iodobenzoyl)piperidine 
• 856015-17-3 (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-piperidine 
• 1723-00-8 (R)-(+)-pipecolic acid 

Relevant academic research and scientific papers

Enantiodivergent synthesis of the quinolizidine poison frog alkaloid 195C

Herein, we describe the enantiodivergent synthesis of the 1,4-cis-disubstituted quinolizidine alkaloid 195C. Although the stereoselectivity of the final hydrogenation reaction was low, we have proposed the first chiral total synthesis of both (-)- and (+)-195C as an enantiodivergent process.

Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Allenes

The rhodium-catalyzed asymmetric intramolecular hydroamination of sulfonyl amides with terminal allenes is reported. It provides selective access to 5- and 6-membered N-heterocycles, scaffolds found in a large range of different bioactive compounds. Moreover, gram scale reactions, as well as the application of suitable product transformations to natural products and key intermediates thereof are demonstrated.

Enantioselective syntheses of (R)-pipecolic acid, (2R,3R)-3-hydroxypipecolic acid, β-(+)-conhydrine and (-)-swainsonine using an aziridine derived common chiral synthon

Concise total syntheses of (R)-pipecolic acid, (R)-ethyl-6-oxopipecolate, (2R,3R)-3-hydroxypipecolic acid and formal syntheses of β-(+)-conhydrine, (-)-lentiginosine, (-)-swainsonine and 1,2-di-epi-swainsonine have been accomplished starting from a common chiral synthon. The present strategy employs regioselective aziridine ring opening, Wittig olefination and RCM as the key chemical transformations.

Stereoselective syntheses of L-pipecolic acid and (2S,3S)-3- hydroxypipecolic acid from a chiral n-imino-2-phenyl-1,2-dihydropyridine intermediate

"Chemical Equation Presented" Stereoselective syntheses of L-pipecolic acid and (2S,3S)3-hydroxypipecolic acid were achieved from a chiral AMmino-2-phenyl-l,2-dihydropyridine intermediate. The 3-hydroxy substituent of the latter amino acid was introduced, by hetero-Diels-Alder reaction of singlet, oxygen with the 1,2-dihydropyridine.

QUINAZOLINE DERIVATIVES

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also

A short synthesis of conformationally constrained unnatural bicyclic amino acids containing a nitrogen atom at the ring juncture: (9aR)- and (9aS)-octahydropyrido[1,2-a]pyrazine-(3S)-carboxylic acids (Opc)

A short and efficient route to conformationally constrained amino acid analogues, (9aR)- and (9aS)-octahydropyrido[1,2-a]pyrazine-(3S)-carboxylate (Opc) has been developed. The new bicyclic amino acid derivatives can be stored and utilized as a modular unit for the construction of unnatural oligopeptides using conventional peptide coupling methods. Georg Thieme Verlag Stuttgart.

INDAZOLYLAMINO QIONAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti-proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blo

INDOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

A quinazoline derivative of the Formula (I) wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.

METHOD FOR SYNTHESISING OPTICALLY ACTIVE PIPERIDINES BY THE HYDROGENATION OF OPTICALLY ACTIVE PYRIDINES

The invention relates to a method for preparing optically active piperidines by the hydrogenation of pyridines using a suitable catalyst. Said method enables the preparation of a plurality of piperidine derivatives with high optical purity and in high yields.

1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents

A series of 1-hydroxyalkyl-3-phenylthiourea analogs were prepared and evaluated as HDL-and Apo A-I-elevating agents. Derivatives 5h, 7j, 7n, and 7o were found to be as effective or superior to gemfibrozil (1).