1545025-44-2

Basic information

• Product Name: 2-amino-4,6-dimethoxybenzonitrile
• Synonyms: 2-amino-4,6-dimethoxybenzonitrile
• CAS NO: 1545025-44-2
• Molecular Weight: 178.191
• Mol File: 1545025-44-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-amino-4,6-dimethoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4,6-dimethoxybenzonitrile(1545025-44-2)
• EPA Substance Registry System: 2-amino-4,6-dimethoxybenzonitrile(1545025-44-2)

Safety Data

• Hazardous Substances Data: 1545025-44-2(Hazardous Substances Data)

Upstream product

• 85657-94-9 N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide 
• 1599437-13-4 N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide 
• 76159-92-7 5,7-dimethoxyisatin 
• 2735-04-8 2,4-Dimethoxyaniline 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 10272-07-8 3.5-dimethoxyaniline 
• 1599437-14-5 2-cyano-3,5-dimethoxytrifluoroacetanilide 

Downstream Products

• 63920-73-0 2-amino-4,6-dimethoxybenzamide 
• 1044870-30-5 2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazolin-4-one 
• 1044870-39-4 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one 

Relevant articles and documents

Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208

Bromodomain-containing protein 4 (BRD4) is a new therapeutic target for the treatment of diseases including cardiovascular diseases, cancer, inflammation and central nervous system (CNS) disorders. In this study, we introduced the pharmacophore of fibrates to a BRD4 inhibitor, RVX-208, to design dual-active hypolipidemic compounds, and found that some of new analogues showed favorable hypolipidemic activities. Synthetic accessibility towards this class of compounds optimized RVX-208 as well as would supply more thoughts on hypolipidemic drugs.

Based on BRD4 inhibitor RVX - 208 of the derivative and its preparation method and application (by machine translation)

The invention discloses a method based on BRD4 inhibitor RVX - 208 of the derivative and its preparation method and application. Derivatives of the structure shown in formula I. The preparation method comprises: type 8 compound of formula 9 compound reaction, [...] 10 compound; type 10 compounds with malonic acid, d di-acid or fifth heavenly stem II acid after the reaction, with vinyl carbonate, 2 - halo of isobutyric acid or 4 - halo [...] butyric acid reaction; or, the type 10 compound directly with ethylene carbonate, 2 - halo of isobutyric acid or 4 - halo [...] butyric acid reaction. The invention also provides its application. The present invention provides based on BRD4 inhibitor RVX - 208 of the derivatives, can improve the activity or at the same time reducing cholesterol lowering cholesterol and triglyceride levels. (by machine translation)

COMPOUNDS USEFUL IN THE SYNTHESIS OF BENZAMIDE COMPOUNDS

Compounds that are useful in the synthesis of 2-amino-4,6-dimethoxybenzamide derivatives and other benzamide compounds.