1599437-13-4

Basic information

• Product Name: N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide
• Synonyms: N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide
• CAS NO: 1599437-13-4
• Molecular Weight: 328.086
• Mol File: 1599437-13-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide(1599437-13-4)
• EPA Substance Registry System: N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide(1599437-13-4)

Safety Data

• Hazardous Substances Data: 1599437-13-4(Hazardous Substances Data)

Upstream product

• 85657-94-9 N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide 
• 10272-07-8 3.5-dimethoxyaniline 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 1132-21-4 3,5-dimethoxybenzoic acid 

Downstream Products

• 1545025-44-2 2-amino-4,6-dimethoxybenzonitrile 
• 1599437-14-5 2-cyano-3,5-dimethoxytrifluoroacetanilide 
• 63920-73-0 2-amino-4,6-dimethoxybenzamide 
• 1044870-30-5 2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazolin-4-one 
• 1044870-39-4 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one 

Relevant articles and documents

Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208

Bromodomain-containing protein 4 (BRD4) is a new therapeutic target for the treatment of diseases including cardiovascular diseases, cancer, inflammation and central nervous system (CNS) disorders. In this study, we introduced the pharmacophore of fibrates to a BRD4 inhibitor, RVX-208, to design dual-active hypolipidemic compounds, and found that some of new analogues showed favorable hypolipidemic activities. Synthetic accessibility towards this class of compounds optimized RVX-208 as well as would supply more thoughts on hypolipidemic drugs.

PROCESSES FOR THE SYNTHESIS OF 2-AMINO-4,6-DIMETHOXYBENZAMIDE AND OTHER BENZAMIDE COMPOUNDS

This invention provides a method for the synthesis of a 2-amino-4,6-dimethoxybenzamide and other benzamides of Compound I: wherein R1, R2, R3, and R4 each independently represent a hydrogen, a C1-C6 alkyl, or a C1-C6 alkoxy; and wherein R6 and R7 each independently represent a hydrogen, a C1-C6 alkyl, a protecting group, or a directing group.