85657-94-9

Upstream product

• 1132-21-4 3,5-dimethoxybenzoic acid 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 10272-07-8 3.5-dimethoxyaniline 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 407-25-0 trifluoroacetic anhydride 
• 75996-26-8 azido(3,5-dimethoxyphenyl)methanone 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 429681-68-5 N-(4-acetyl-3,5-dimethoxyphenyl)trifluoroacetamide 
• 429681-67-4 N-(2-acetyl-3,5-dimethoxyphenyl)trifluoroacetamide 
• 1599437-13-4 N-(2-bromo-3,5-dimethoxybenzene)-2,2,2-trifluoroacetamide 
• 63920-73-0 2-amino-4,6-dimethoxybenzamide 
• 1044870-30-5 2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazolin-4-one 
• 1044870-39-4 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one 
• 1599437-15-6 2,4-dibromo-3,5-dimethoxytrifluoroacetanilide 
• 1603827-26-4 C₁₀H₉BrF₃NO₃ 
• 1603827-27-5 C₁₀H₈Br₂F₃NO₃ 
• 1545025-44-2 2-amino-4,6-dimethoxybenzonitrile 
• 1378670-58-6 C₉H₁₀N₂O₂ 
• 1026932-90-0 benzoic acid 2-acetyl-3-methoxy-5-(2,2,2-trifluoro-acetylamino)-phenyl ester 
• 429681-70-9 N-(4-acetyl-3-hydroxy-5-methoxyphenyl)trifluoroacetamide 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208

Bromodomain-containing protein 4 (BRD4) is a new therapeutic target for the treatment of diseases including cardiovascular diseases, cancer, inflammation and central nervous system (CNS) disorders. In this study, we introduced the pharmacophore of fibrates to a BRD4 inhibitor, RVX-208, to design dual-active hypolipidemic compounds, and found that some of new analogues showed favorable hypolipidemic activities. Synthetic accessibility towards this class of compounds optimized RVX-208 as well as would supply more thoughts on hypolipidemic drugs.

Based on BRD4 inhibitor RVX - 208 of the derivative and its preparation method and application (by machine translation)

The invention discloses a method based on BRD4 inhibitor RVX - 208 of the derivative and its preparation method and application. Derivatives of the structure shown in formula I. The preparation method comprises: type 8 compound of formula 9 compound reaction, [...] 10 compound; type 10 compounds with malonic acid, d di-acid or fifth heavenly stem II acid after the reaction, with vinyl carbonate, 2 - halo of isobutyric acid or 4 - halo [...] butyric acid reaction; or, the type 10 compound directly with ethylene carbonate, 2 - halo of isobutyric acid or 4 - halo [...] butyric acid reaction. The invention also provides its application. The present invention provides based on BRD4 inhibitor RVX - 208 of the derivatives, can improve the activity or at the same time reducing cholesterol lowering cholesterol and triglyceride levels. (by machine translation)

PROCESSES FOR THE SYNTHESIS OF 2-AMINO-4,6-DIMETHOXYBENZAMIDE AND OTHER BENZAMIDE COMPOUNDS

This invention provides a method for the synthesis of a 2-amino-4,6-dimethoxybenzamide and other benzamides of Compound I: wherein R1, R2, R3, and R4 each independently represent a hydrogen, a C1-C6 alkyl, or a C1-C6 alkoxy; and wherein R6 and R7 each independently represent a hydrogen, a C1-C6 alkyl, a protecting group, or a directing group.

COMPOUNDS USEFUL IN THE SYNTHESIS OF BENZAMIDE COMPOUNDS

Compounds that are useful in the synthesis of 2-amino-4,6-dimethoxybenzamide derivatives and other benzamide compounds.

CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula (I), o

Diaminopyrimidines as P2X3 and P2X2/3 modulators

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, Rs

Acetylated dimethoxyaniline as a key intermediate for the synthesis of aminoflavones and quinolones

3,5-Dimethoxyaniline was acetylated and found to be a key intermediate for the synthesis of a variety of biologically active aminoflavones and quinolones.