154520-13-5

Upstream product

• 57244-09-4 2-Cyanobutanoyl chloride 
• 51789-75-4 1-cyano-propane-1-carboxylic acid 
• 610784-26-4 (2RS)-(1'S,2'R,4'R)-10'-(dicyclohexylsulfamoyl)isobornyl-2-cyanobutanoate 
• 74-88-4 methyl iodide 
• 75-03-6 ethyl iodide 
• 188183-27-9 (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyanopropanoate 

Downstream Products

• 154520-23-7 (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-methylbutanoate 

Relevant academic research and scientific papers

Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

A new strategy for the preparation of both enantiomers of 2-amino-2-methylbutanoic acid (Iva) based on diastereoselective alkylation of (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyanoesters and the corresponding degradation process is described.

Asymmetric Synthesis of β-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

Enolates derived from 10-(dicyclohexylsulfamoyl)isobornyl 2-substituted-2-cyanoacetates were alkylated with very good yield and high diastereoselectivity.The reduction of the resulting reaction products and subsequent cyclization of the β-amino acids led