Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

Article abstract of DOI:10.1016/S0957-4166(00)80337-7

A new strategy for the preparation of both enantiomers of 2-amino-2-methylbutanoic acid (Iva) based on diastereoselective alkylation of (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyanoesters and the corresponding degradation process is described.