Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

DOI: 10.1016/S0957-4166(00)80337-7

Source and publish data:

Tetrahedron Asymmetry p. 1445 - 1448 (1993)

Update date:2022-08-05

Topics:

Authors:

Cativiela, Carlos

Diaz-de-Villegas, Maria D.

Galvez, Jose A.

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Article abstract of DOI:10.1016/S0957-4166(00)80337-7

A new strategy for the preparation of both enantiomers of 2-amino-2-methylbutanoic acid (Iva) based on diastereoselective alkylation of (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyanoesters and the corresponding degradation process is described.

Full text of DOI:10.1016/S0957-4166(00)80337-7

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Product name:(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-methylbutanoate

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