154532-34-0

Usage

Uses

Used in Rubber Production Industry:
BUTTPARK 148\01-24 is used as a vulcanization accelerator for improving the physical and mechanical properties of rubber. It is applied to increase the strength and resilience of rubber materials, which is essential for the production of durable and high-performance rubber goods.
Used in Tire Manufacturing:
In the tire manufacturing process, BUTTPARK 148\01-24 is used as a critical component to ensure the tires have enhanced durability and performance. The vulcanization process, accelerated by this chemical blend, results in tires with improved load-bearing capacity and resistance to wear and tear.
Used in Conveyor Belt Production:
For conveyor belt manufacturing, BUTTPARK 148\01-24 is utilized to create belts with superior resistance to abrasion and increased flexibility. This leads to belts that are more reliable and longer-lasting in demanding industrial environments.
Used in Other Industrial Rubber Products:
BUTTPARK 148\01-24 is also used in the production of various other industrial rubber products where high strength, resilience, and durability are required. Its application ensures that these products can withstand the rigors of their intended use, providing both reliability and longevity.

Upstream product

• 3972-64-3 1-bromo-3-(tertbutyl)benzene 
• 253185-03-4 tert-butylbenzene 
• 460-19-5 ethanedinitrile 
• 557-21-1 dicyanozinc 
• 201851-06-1 m-(tert-butyl)phenyl trifluoromethanesulfonate 
• 626-17-5 benzene-1,3-dicarbonitrile 
• 85-01-8 phenanthrene 
• 1184-88-9 sodium pivalate 
• 585-34-2 3-tert-butylphenyol 
• 330660-35-0 silver cyanide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 865-47-4 potassium tert-butylate 
• 71-43-2 benzene 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 7498-54-6 3-t-Butylbenzoic acid 
• 140401-55-4 3-tert-Butyl-benzylamine; hydrochloride 
• 608515-16-8 (3-(tert-butyl)phenyl)methanamine 
• 1385069-07-7 tert-butyl 3-(tert-butyl)benzylcarbamate 
• 1385067-81-1 N-((E)-(S)-4-[(R)-2-(3-tert-butyl-benzylamino)-1-hydroxy-ethyl]-2,13-dioxo-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁷⁾,8,14⁽¹⁸⁾,15-tetraen-16-yl)-N-methyl-methanesulfonamide 
• 900802-72-4 1-(3-tert-butyl-phenyl)-cyclo-propylamine 

Relevant academic research and scientific papers

Covalently Interlocked Cyclohexa-m-phenylenes and Their Assembly: En Route to Supramolecular 3D Carbon Nanostructures

In our search to cluster as many phenylene units as possible in a given space, we have proceeded to the three-dimensional world of benzene-based molecules by employing covalently interlocked cyclohexa-m-phenylenes, as present in the unique paddlewheel-sha

Ligand-Promoted Non-Directed C?H Cyanation of Arenes

This article reports the first example of a 2-pyridone accelerated non-directed C?H cyanation with an arene as the limiting reagent. This protocol is compatible with a broad scope of arenes, including advanced intermediates, drug molecules, and natural products. A kinetic isotope experiment (kH/kD=4.40) indicates that the C?H bond cleavage is the rate-limiting step. Also, the reaction is readily scalable, further showcasing the synthetic utility of this method.

Palladium-Catalyzed Late-Stage Direct Arene Cyanation

Methods for direct benzonitrile synthesis are sparse, despite the versatility of cyano groups in organic synthesis and the importance of benzonitriles for the dye, agrochemical, and pharmaceutical industries. We report the first general late-stage aryl C–H cyanation with broad substrate scope and functional-group tolerance. The reaction is enabled by a dual-ligand combination of quinoxaline and an amino acid-derived ligand. The method is applicable to direct cyanation of several marketed small-molecule drugs, common pharmacophores, and organic dyes. Benzonitriles are some of the most versatile building blocks for organic synthesis, in particular in the pharmaceutical industry, but general methods to make them by direct C–H functionalization are unknown. In this issue of Chem, Ritter and coworkers describe a late-stage aryl C–H cyanation with broad substrate scope and functional-group tolerance, enabled by a palladium-dual-ligand catalyst system. The reaction may serve for the late-stage modification of drug candidates. Aryl nitriles constitute an important class of organic compounds that are widely found in natural products, pharmaceuticals, agricultural chemicals, dyes, and materials. Moreover, nitriles are versatile building blocks to access numerous other important molecular structure groups. However, no general method for direct aromatic C–H cyanation is known. All approaches to date require either an appropriate directing group or reactive electron-rich substrates, such as indoles, which limit their synthetic applications. Here we describe an undirected, palladium-catalyzed late-stage aryl C–H cyanation reaction for the synthesis of complex aryl nitriles that would otherwise be more challenging to produce. The wide substrate scope and good functional-group tolerance of this reaction provide direct and quick access to structural diversity for pharmaceutical and agrochemical development.

Dual Ligand-Enabled Nondirected C-H Cyanation of Arenes

Aromatic nitriles are key structural units in organic chemistry and, therefore, highly attractive targets for C-H activation. Herein, the development of an arene-limited, nondirected C-H cyanation based on the use of two cooperatively acting commercially available ligands is reported. The reaction enables the cyanation of arenes by C-H activation in the absence of directing groups and is therefore complementary to established approaches.

A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling

Several diketopiperazines have been shown to promote carbon-carbon coupling between benzene and aryl halides in the presence of potassium tert-butoxide and without the assistance of a transition metal catalyst. The structure of the diketopiperazine has an influence on its reductive potential and can help to promote the coupling of the more challenging aryl bromides with benzene.

Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes

A series of P1-P3 linked macrocyclic BACE-1 inhibitors containing a hydroxyethylamine (HEA) isostere scaffold has been synthesized. All inhibitors comprise a toluene or N-phenylmethanesulfonamide P2 moiety. Excellent BACE-1 potencies, both in enzymatic an

Decarboxylative photosubstitution of dicyanobenzenes with aliphatic carboxylate ions

The photoreaction of dicyanobenzenes with aliphatic carboxylate ions afforded alkylcyanobenzenes and alkyldicyanobenzenes via decarboxylative substitution. The redox-photosensitized reaction system was effective in improving the product yield. The efficie

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)

Macrocyclic Compounds Useful as Bace Inhibitors

The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

MACROCYCLIC COMPOUNDS AND COMPOSITIONS USEFUL AS BACE INHIBITORS

The invention relates to novel macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms include