154612-64-3

Basic information

• Product Name: tert-butyl 4-(phenylthio)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(phenylthio)piperidine-1-carboxylate
• CAS NO: 154612-64-3
• Molecular Weight: 293.43
• Mol File: 154612-64-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(phenylthio)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(phenylthio)piperidine-1-carboxylate(154612-64-3)
• EPA Substance Registry System: tert-butyl 4-(phenylthio)piperidine-1-carboxylate(154612-64-3)

Safety Data

• Hazardous Substances Data: 154612-64-3(Hazardous Substances Data)

Upstream product

• 882-33-7 diphenyldisulfane 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 1872262-73-1 1-(tert-butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate 
• 108-98-5 thiophenol 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 

Downstream Products

• 151666-11-4 2-chloro-N-[4-(phenylthio)-1-piperidinyl]adenosine 
• 151666-25-0 1-Amino-4-phenylthiopiperidine 
• 285994-99-2 1-[2-(4-fluorophenyl)-2-oxoethyl]-4-phenylsulphonylpiperidine 
• 400729-18-2 tert-butyl 4-(phenylsulfonyl)piperidine-1-carboxylate 

Relevant articles and documents

Visible Light-Driven Decarboxylative Alkylation of Aldehydes via Electron Donor–Acceptor Complexes of Active Esters

There are some synthesis methods from widely available aldehydes to the corresponding ketones, however, they involved in multistep reactions with Grignard’s reagents or transition metal catalysts. In this paper, we have developed photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes. The photochemical reactions are initiated via photoinduced single electron transfer from triethylamine to N-hydroxyphthalimide esters in electron donor–acceptor complexes. This photochemical method can achieve to translate 15 pyridinaldehydes and 11 2-quinolinaldehydes to the corresponding ketones. Furthermore, this strategy can also achieve two other transformations, disulfanes to aryl sulfides and a styrene sulfone to the alkyl-substituted alkene.

Copper-Catalyzed Intermolecular Functionalization of Unactivated C(sp3)-H Bonds and Aliphatic Carboxylic Acids

Intermolecular functionalization of C(sp3)-H bonds and aliphatic carboxylic acids enables the efficient synthesis of high value-added organic compounds from readily available starting materials. Although methods involving hydrogen atom transfer have been developed for such functionalization, these methods either work for only activated C(sp3)-H bonds or bring in a narrow set of functional groups. Here we describe a Cu-catalyzed process for the diverse functionalization of both unactivated C(sp3)-H bonds and aliphatic carboxylic acids. The process is enabled by the trapping of alkyl radicals generated through hydrogen atom abstraction by arylsulfonyl-based SOMO-philes, which introduces a large array of C, N, S, Se, and halide-based functional groups. The chemoselectivity can be switched from C-H functionalization to decarboxylative functionalization by matching the bond dissociation energy of the hydrogen atom transfer reagent with that of the target C-H or O-H bond.

Process for alkylation of group VI compound

The invention provides a process for alkylation of a group VI compound. Under an illumination condition, an active ester with a general formula of Ra-COONPhth and a main group VI compound with a general formula of Rb-A-Rc undergo the following reaction un