154669-34-8

Upstream product

• 30125-76-9 1-(phenylmethyl)pyrrolidine-2,4-dione 
• 67513-35-3 ethyl 1-benzyl-4-hydroxy-3-pyrrolin-2-one-3-carboxylate 
• 30130-96-2 ethyl N-(ethoxycarbonylacetyl)-N-benzylglycinate 
• 6436-90-4 ethyl 2-(benzylamino)acetate 

Downstream Products

• 154669-38-2 1-Benzyl-3-tert-butoxy-1,5-dihydro-4-hydroxy-2-pyrrolon 
• 87259-92-5 N-benzylstaurosporinone 
• 154669-40-6 1-Benzyl-1,5-dihydro-3,4-dihydroxy-2-pyrrolon 

Relevant academic research and scientific papers

Design and implementation of an efficient synthetic approach to furanosylated indolocarbazoles: Total synthesis of (+)- and (-)-K252a

The first total synthesis of the natural product (+)-K252a (2) has been achieved in 12 steps from commercially available materials, with a longest linear sequence of seven steps and an overall yield of 21%. The synthetic strategy employs novel rhodium carbenoid chemistry in the construction of both the indolocarbazole aglycon (4) and the carbohydrate moiety (9).

Reductones of Tetronic, Thiotetronic and Tetramic Acids, II. - Reductones by Rhodium-Catalyzed Decomposition of Diazo Compounds

The diazoketones 2 have been synthesized by diazo transfer reaction with 2-azido-3-ethylbenzthiazolium tetrafluoroborate.The rhodium-catalyzed decomposition of compounds 2 in tert-butyl alcohol at 130 deg C furnishes the reductone monoethers 3 and after deprotection the aci-reductones 4.Methylation of compounds 4 with diazomethane proceeds stepwise leading first to the monoethers 5 and then to the diethers 6.The thiolactone 4b and even more the lactams 4c and 4d are stronger reducing agents than the lactone 4a. - Key Words: 2,4-Oxolandiones / 2,4-Thiolandiones / 2,4-Pyrrolidindiones / Reductones / Diazo compounds