30130-96-2Relevant articles and documents
Facile access to 3-alkyl-substituted 3-hydroperoxy-2,4-pyrrolidinediones using manganese(III)-catalyzed aerobic oxidation
Haque, M. Aminul,Nishino, Hiroshi
scheme or table, p. 608 - 619 (2011/12/04)
3-Alkyl-substituted 2,4-pyrrolidinediones were directly oxidized under very mild manganese(III)-catalyzed aerobic oxidation conditions to give the corresponding 3-hydroperoxy-2,4-pyrrolidinediones in quantitative yields. The scope and limitations for the
Short and versatile route to a key intermediate for lactacystin synthesis.
Bulman Page, Philip C,Hamzah, A Sazali,Leach, David C,Allin, Steven M,Andrews, David M,Rassias, Gerasimos A
, p. 353 - 355 (2007/10/03)
[reaction: see text] A key intermediate 14 for the synthesis of lactacystin 1 has been constructed in four steps and 33% overall yield. The key steps involve cyclization of a suitably functionalized glutamic acid derivative and concomitant alkylation of the resulting beta,beta-diketoester system, C-acylation of the cyclic alpha-amidoketone 9, and decarboxylbenzylation of 12. Alkylation of a related beta,beta-diketoester 5 was additionally achieved with several electrophiles.
Design and implementation of an efficient synthetic approach to furanosylated indolocarbazoles: Total synthesis of (+)- and (-)-K252a
Wood, John L.,Stoltz, Brian M.,Dietrich, Hans-Jürgen,Pflum, Derek A.,Petsch, Dejah T.
, p. 9641 - 9651 (2007/10/03)
The first total synthesis of the natural product (+)-K252a (2) has been achieved in 12 steps from commercially available materials, with a longest linear sequence of seven steps and an overall yield of 21%. The synthetic strategy employs novel rhodium carbenoid chemistry in the construction of both the indolocarbazole aglycon (4) and the carbohydrate moiety (9).
