155-15-7

Basic information

• Product Name: 5-FLUORO-1-METHYL-CYTOSINE
• Synonyms: 4-amino-5-fluoro-1-methyl-pyrimidin-2-one;4-amino-5-fluoro-1-methylpyrimidin-2-one;4-azanyl-5-fluoro-1-methyl-pyrimidin-2-one;4-AMino-5-fluoro-1-MethylpyriMidin-2(1H)-one;5-FLUORO-1-METHYL-CYTOSINE
• CAS NO: 155-15-7
• Molecular Formula: C5H6FN3O
• Molecular Weight: 143.1190432
• Mol File: 155-15-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 209 °C at 760 mmHg
• Flash Point: 80.2 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 0.207mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 5-FLUORO-1-METHYL-CYTOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-1-METHYL-CYTOSINE(155-15-7)
• EPA Substance Registry System: 5-FLUORO-1-METHYL-CYTOSINE(155-15-7)

Safety Data

• Hazardous Substances Data: 155-15-7(Hazardous Substances Data)

Usage

General Description

5-Fluoro-1-methyl-cytosine is a synthetic chemical compound that is structurally similar to cytosine, one of the four nucleobases found in DNA and RNA. It is a modified form of cytosine with a fluorine atom at the 5th position and a methyl group at the 1st position. This modification can affect the compound's properties, such as its stability, reactivity, and biological activity. 5-Fluoro-1-methyl-cytosine has been studied for its potential as an antiviral and anticancer agent due to its ability to inhibit the replication of certain viruses and tumor cells. It is also used as a research tool in molecular biology and biochemistry for studying nucleic acid structure and function.

InChI:InChI=1/C5H6FN3O/c1-9-2-3(6)4(7)8-5(9)10/h2H,1H3,(H2,7,8,10)

Upstream product

• 66-27-3 Methyl methanesulfonate 
• 2022-85-7 4-amino-5-fluoro-pyrimidin-2-ol 
• 2022-85-7 Flucytosine 
• 74-88-4 methyl iodide 
• 1122-47-0 1-methylcytosine 
• 2022-85-7 5-fluorocytosine 
• 72939-80-1 5-Fluoro-4-hydroxy-6-imino-tetrahydro-pyrimidin-2-one 
• 512-56-1 trimethyl phosphite 

Relevant articles and documents

Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: Mass spectrometric evidence for the presence of a trapped water molecule

Cytidine deaminase (CDA) binds the inhibitor zebularine as its 3,4-hydrate (Kd ～ 10-12 M), capturing all but ～5.6 kcal/mol of the free energy of binding expected of an ideal transition state analogue (Ktx ～ 10-16 M). On the basis of its entropic origin, that shortfall was tentatively ascribed to the trapping of a water molecule in the enzyme-inhibitor complex, as had been observed earlier for product uridine [Snider, M. J., and Wolfenden, R. (2001) Biochemistry 40, 11364-11371]. Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) of CDA nebularized in the presence of saturating 5-fluorozebularine reveals peaks corresponding to the masses of E2Zn2W2 (dimeric Zn-CDA with two water molecules), E2Zn2W2Fz, and E2Zn2W2Fz2, where Fz represents the 3,4-hydrate of 5-fluorozebularine. In the absence of an inhibitor, E 2Zn2 is the only dimeric species detected, with no additional water molecules. Experiments conducted in H218O indicate that the added mass W represents a trapped water molecule rather than an isobaric ammonium ion. This appears to represent the first identification of an enzyme-bound water molecule at a subunit interface (active site) using FTICR-MS. The presence of a 5-fluoro group appears to retard the decomposition of the inhibitory complex kinetically in the vapor phase, as no additional dimeric complexes (other than E2Zn2) are observed when zebularine is used in place of 5-fluorozebularine. Substrate competition assays show that in solution zebularine is released from CDA (koff > 0.14 s-1) much more rapidly than is 5-fluorozebularine (koff = 0.014 s-1), despite the greater thermodynamic stability of the zebularine complex.

5-FLUOROPYRIMIDINONE DERIVATIVES

This present disclosure is related to the field of 5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.

Glorination of Pyrimidines. Part 2. Mechanistic Aspects of the Reaction of Acetyl Hypofluorite with Uracil and Cytosine Derivatives

The reaction of acetyl hypofluorite (AcOF) with uracil, cytosine, and some N-1-substituted derivatives dissolved in either acetic acid or water has been investigated.Analysis by radio-h.p.l.c., using (18)f as a tracer, and by (1)H n.m.r. revealed that a substituent at N-1 of uracil has a remarkable effect on the stability of the intermediate 6-acetoxy-5-fluoro-5,6-dihydrouracils.In addition, it was found that these cytosine adducts rapidly deaminate in water yielding their corresponding uracil analogues.